Clinical Trial: Impact of Bacterial Expression and Immune Response in the Severity of Pertussis
Study Status: NOT_YET_RECRUITING
Recruit Status: NOT_YET_RECRUITING
Condition: Bordetella Pertussis, Whooping Cough
Study Type: INTERVENTIONAL
Official Title: Impact of Bacterial Expression and Immune Response in the Severity of Pertussis
Brief Summary:
The resurgence of pertussis is associated with an evolutionary mechanism under the pressure of current acellular vaccines, with a possible impact on vaccine effectiveness and disease expression.Little is known about the mechanisms involved in the clinical variability of pertussis, including its most severe malignant form observed in infants (mortality between 50-80%).The main challenges are: (i) the lack of knowledge about the gene expression of B. pertussis strains currently circulating during human infection,…
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