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First received: July 11, 2023

Clinical Trial: Frequency and E-field Enhancement of ITBS for Depression (FREED)

Study Status: Completed

Recruit Status: RECRUITING

Condition: Major Depressive Disorder

Study Type: INTERVENTIONAL


Official Title: Frequency and E-field Enhancement of ITBS for Depression (FREED)

Brief Summary: The investigators propose a randomized 3-arm double-blinded parallel experimental trial (20 sessions over 4 weeks) in 75 patients with TRD.The three arms include (1) the combination of a fully Individualized form of intermittent Theta Burst Stimulation (iTBS) (using BOTH the frequency and electric field (E-field) targeting approaches) (Ind-iTBS)), (2) iTBS individualized using E-field targeting only (targeted-iTBS) and (3) Standard iTBS treatment (i.e., typical iTBS localized to the dorsolateral prefrontal cortex…

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