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First received: March 01, 2023

Clinical Trial: High vs.Standard Dose Influenza Vaccine in Pediatric SOT Recipients

Study Status: NOT_YET_RECRUITING

Recruit Status: NOT_YET_RECRUITING

Condition: Immunization; Infection

Study Type: INTERVENTIONAL


Official Title: Comparison of High vs Standard Dose Influenza Vaccines in Pediatric Solid Organ Transplant Recipients

Brief Summary: Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients.However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV).Recent studies have investigated two strategies to overcome poor immune responses in SOT recipients: (1) administration of high-dose (HD)-IIV compared to SD-IIV and (2) two doses of SD-IIV compared to one dose of SD-IIV in the same influenza season.One study compared HD-IIV vs. SD-IIV in adult SOT recipients and noted that…

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