Clinical Trial: High vs.Standard Dose Influenza Vaccine in Pediatric SOT Recipients
Study Status: NOT_YET_RECRUITING
Recruit Status: NOT_YET_RECRUITING
Condition: Immunization; Infection
Study Type: INTERVENTIONAL
Official Title: Comparison of High vs Standard Dose Influenza Vaccines in Pediatric Solid Organ Transplant Recipients
Brief Summary:
Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients.However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV).Recent studies have investigated two strategies to overcome poor immune responses in SOT recipients: (1) administration of high-dose (HD)-IIV compared to SD-IIV and (2) two doses of SD-IIV compared to one dose of SD-IIV in the same influenza season.One study compared HD-IIV vs. SD-IIV in adult SOT recipients and noted that…
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