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First received: August 01, 2023

Clinical Trial: Hyperbaric Oxygen Therapy for Ulcerative Colitis

Study Status: NOT_YET_RECRUITING

Recruit Status: NOT_YET_RECRUITING

Condition: Ulcerative Colitis

Study Type: INTERVENTIONAL


Official Title: Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial

Brief Summary: Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC).Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation.Two small prospective randomized controlled trials have demonstrated that the delivery of HBOT to UC patients hospitalized for acute moderate to severe flares results in improved remission rates and avoidance of in-hospital progression to biologics, small molecules, or…

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