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First received: January 13, 2023

Clinical Trial: Amplitude Titration to Improve ECT Clinical Outcomes

Study Status: Completed

Recruit Status: RECRUITING

Condition: Depression

Study Type: INTERVENTIONAL


Official Title: Amplitude Titration to Improve ECT Clinical Outcomes Randomized Clinical Trial

Brief Summary: A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total).Relative to fixed 800 mA ECT:H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2).H2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-Verbal Fluency

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