Clinical Trial: Amplitude Titration to Improve ECT Clinical Outcomes
Study Status: Completed
Recruit Status: RECRUITING
Condition: Depression
Study Type: INTERVENTIONAL
Official Title: Amplitude Titration to Improve ECT Clinical Outcomes Randomized Clinical Trial
Brief Summary:
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total).Relative to fixed 800 mA ECT:H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2).H2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-Verbal Fluency
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