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First received: September 18, 2023

Clinical Trial: Bumetanide in Patients With Alzheimer's Disease

Study Status: NOT_YET_RECRUITING

Recruit Status: NOT_YET_RECRUITING

Condition: Alzheimer Disease

Study Type: INTERVENTIONAL


Official Title: Phase IIa, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Tolerability of Bumetanide in Patients With Alzheimer's Disease.

Brief Summary: This study aims to investigate bumetanide in patients with biologically confirmed Alzheimer's disease (AD).Bumetanide is a potent diuretic administered orally and is FDA approved for the treatment of edema and hypertension.Repurposing bumetanide as a medication for AD has been proposed based on data that demonstrated its ability to "flip" the APOE genotype-dependent transcriptomic signatures in AD mouse and cell culture models.Critically, this discovery was subsequently explored in Electronic Health…

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