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First received: July 18, 2023

Clinical Trial: Naltrexone and Propranolol Combined With Immunotherapy

Study Status: Completed

Recruit Status: RECRUITING

Condition: Advanced Melanoma

Study Type: INTERVENTIONAL


Official Title: A Phase I Study to Evaluate the Safety of Naltrexone and Propranolol in Combination With Standard of Care Ipilimumab and Nivolumab in Patients With Advanced Melanoma

Brief Summary: Various forms of stress can promote cancer development and growth and negatively impact the immune system's response to tumors.Beta-adrenergic and opioid receptors co-exist in many cells including immune cells and are integral components of the body's response to stress.Pre-clinical studies have demonstrated that dual blockade of these receptors can decrease tumor growth and modulate the anti-tumor immune response.This clinical trial investigates the safety and potential therapeutic benefits of combining…

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