Clinical Trial: Naltrexone and Propranolol Combined With Immunotherapy
Study Status: Completed
Recruit Status: RECRUITING
Condition: Advanced Melanoma
Study Type: INTERVENTIONAL
Official Title: A Phase I Study to Evaluate the Safety of Naltrexone and Propranolol in Combination With Standard of Care Ipilimumab and Nivolumab in Patients With Advanced Melanoma
Brief Summary:
Various forms of stress can promote cancer development and growth and negatively impact the immune system's response to tumors.Beta-adrenergic and opioid receptors co-exist in many cells including immune cells and are integral components of the body's response to stress.Pre-clinical studies have demonstrated that dual blockade of these receptors can decrease tumor growth and modulate the anti-tumor immune response.This clinical trial investigates the safety and potential therapeutic benefits of combining…
Read more