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First received: February 06, 2023

Clinical Trial: FUS Etoposide for DMG - A Feasibility Study

Study Status: Completed

Recruit Status: RECRUITING

Condition: Diffuse Intrinsic Pontine Glioma

Study Type: INTERVENTIONAL


Official Title: A Feasibility Study Examining the Use of Non-Invasive Focused Ultrasound (FUS) With Oral Etoposide Administration in Children With Progressive Diffuse Midline Glioma (DMG)

Brief Summary: The blood brain barrier (BBB) prevents some drugs from successfully reaching the target tumor.Focused Ultrasound (FUS) using microbubbles and neuro-navigator controlled sonication is a non-invasive method of temporarily opening up the blood brain barrier to allow a greater concentration of the drug to reach into the brain tumor.This may improve response and may also reduce system side effects in the patient.The primary purpose of this study is to evaluate the feasibility of safely opening the blood brain barrier…

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