Clinical Trial: Predicting Cognitive Decline From Androgen Deprivation Therapy
Study Status: Completed
Recruit Status: RECRUITING
Condition: Prostate Cancer
Study Type: OBSERVATIONAL
Official Title: Plasma Amyloid-beta 42/40 to Predict Cognitive Decline From Androgen Deprivation Therapy in Prostate Cancer: a Prospective Observational Study
Brief Summary:
Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer.Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the hippocampus, a pathological hallmark of Alzheimer's Disease (AD).Neuroimaging Functional magnetic resonance imaging (fMRI) studies also demonstrate that ADT decreases metabolic activity in the parietal, occipital, and prefrontal cortices.Multiple prospective cohort and population-based…
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