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First received: April 07, 2023

Clinical Trial: Predicting Cognitive Decline From Androgen Deprivation Therapy

Study Status: Completed

Recruit Status: RECRUITING

Condition: Prostate Cancer

Study Type: OBSERVATIONAL


Official Title: Plasma Amyloid-beta 42/40 to Predict Cognitive Decline From Androgen Deprivation Therapy in Prostate Cancer: a Prospective Observational Study

Brief Summary: Androgen Deprivation Therapy (ADT) is associated with cognitive impairment and dementia in men with prostate cancer.Pre-clinical data suggest that ADT-induced hypogonadism leads to accumulation of beta-amyloid plaques in the hippocampus, a pathological hallmark of Alzheimer's Disease (AD).Neuroimaging Functional magnetic resonance imaging (fMRI) studies also demonstrate that ADT decreases metabolic activity in the parietal, occipital, and prefrontal cortices.Multiple prospective cohort and population-based…

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