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First received: August 01, 2023

Clinical Trial: BioFLO for Respiratory Recovery in SCI

Study Status: Completed

Recruit Status: RECRUITING

Condition: Spinal Cord Injuries

Study Type: INTERVENTIONAL


Official Title: Genetic Biomarkers of Intermittent Hypoxia-Induced Respiratory Motor Plasticity in Chronic SCI

Brief Summary: Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing low oxygen air to stimulate spinal neuroplasticity.Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic AIH; AIHH) and task-specific training.Using a double blind cross-over design, the study will test whether AIHH improves breathing more than AIH and whether specific genetic variations are related to individuals'…

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