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First received: August 03, 2023

Clinical Trial: Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation

Study Status: Completed

Recruit Status: RECRUITING

Condition: IBS

Study Type: INTERVENTIONAL


Official Title: An Open-label, Single Center Investigator Sponsored Study Assessing the Effect of Tenapanor on Metagenomic and Metabolomic Markers in Patients With Irritable Bowel Syndrome With Constipation

Brief Summary: The aim of this study is to better understand how tenapanor affects the metagenomics and metabolomics of patients with irritable bowel syndrome with constipation (IBS-C).Tenapanor is the newest FDA-approved agent for IBS-C.It is a small molecule that inhibits the NHE3 receptor, leading to impaired sodium and water absorption in the intestine.Previous clinical trials comparing tenapanor to placebo showed that a 50 mg dose of tenapanor led to increased bowel movements and decreased abdominal pain.This study consists…

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