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First received: January 26, 2023

Clinical Trial: Folinic Acid for Prevention of Pemetrexed-induced Toxicity

Study Status: Completed

Recruit Status: RECRUITING

Condition: NSCLC

Study Type: INTERVENTIONAL


Official Title: The Effect of Oral Folinic Acid Rescue Therapy on Pemetrexed Induced Neutropenia: A Randomized Open-label Trial

Brief Summary: Objective The main objective is to evaluate the haematological toxicity in patients who use pemetrexed with and without rescue therapy with folinic acid.Primary endpoint Difference between treatment groups in neutrophil count (*109/L) at day 8-10 after administration of pemetrexed (nadir).Secondary endpoints The grade neutropenia (according to the CTCAE version 5, 2017) at day 8-10, the homocysteine plasma levels at baseline (predictor for developing toxicity), the efficacy of chemotherapy treatment based on…

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