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First received: April 08, 2025

Clinical Trial: Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing

Study Status: COMPLETED

Recruit Status: COMPLETED

Condition: Type 2 Diabetes Mellitus (T2DM)

Study Type: INTERVENTIONAL


Official Title: Evaluation of the Effectiveness of Root Canal Treatment Performed Using Photodynamic Therapy in Teeth With Apical Periodontitis in Patients With Type 2 Diabetes Through Next-Generation Sequencing Micr

Brief Summary: This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical periodontitis (AP).T2DM is known to negatively impact the healing of periapical tissues due to impaired immune response.In this study, methylene blue is used as a photosensitizer, activated by a specific wavelength of light to eliminate residual bacteria that are difficult to reach with…

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