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First received: August 07, 2024

Clinical Trial: A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)

Study Status: COMPLETED

Recruit Status: COMPLETED

Condition: Generalized Lipodystrophy

Study Type: INTERVENTIONAL


Official Title: A Single-Arm, Open-Label, Safety Study in Patients With Generalized Lipodystrophy Switching From Metreleptin to Mibavademab, A Leptin Receptor Agonist Antibody

Brief Summary: This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months.The aim of the study is to see how safe and tolerable mibavademab is when switching from treatment with metreleptin.The study is looking at several other research questions, including:* What side effects may happen from taking mibavademab* How much mibavademab is in the blood at different times*…

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