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Research Article: Effects of pre-eclampsia/eclampsia on platelet parameters in small for gestational age preterm infants

Date Published: 2025-08-26

Abstract:
To investigate whether pre-eclampsia/eclampsia (PE/E) alters platelet parameters, including platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW), in small for gestational age (SGA) infants. We enrolled 245 SGA preterm infants between 2020 and 2023. They were grouped according to their mother's PE/E status. We assessed the PLT, MPV, PDW, and prevelence of thrombocytopenia during the first 30 days after birth. Groups were compared using either ? 2 test or Fisher's exact test. SGA neonates born to mothers with PE/E had a lower PLT on Day 7 than those born to mothers without PE/E ( P =?0.0211). PDW and MPV values gradually increased for the first several days, and eventually stabilized around the first week. There was no statistical difference in MPV, PDW, or thrombocytopenia prevalence between SGA neonates between born to mothers with PE/E and those born to mothers without PE/E. Evidence to support an association between PE/E and platelets parameter in neonates is limited. SGA may be the real reason for alterations in platelet parameters in neonates.

Introduction:
Small for gestational age (SGA) infants are those whose birth weight (BW) is below the 10th percentile for gestational age (GA) and sex compared to a given reference population ( 1 ). Global estimates for 2020 suggest that 13.4 million live births were preterm, with rates over the past decade remaining static, and 23.4 million were SGA ( 2 ). There is a a higher proportion of SGA infants among term and preterm infant in low-income countries compared to high income countries ( 3 , 4 ). The prevalence of preterm SGA…

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