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Draft a comprehensive differential diagnosis for acute substernal chest pain in a 45-year-old male with hypertension and hyperlipidemia, diaphoresis, exertional onset, and normal initial ECG/troponin; include life-threatening causes first, key distinguishing features, and immediate diagnostic next steps.

Draft a detailed differential diagnosis for new-onset unilateral throbbing headache with visual aura and brief monocular vision loss in a 32-year-old female on oral contraceptives; include red-flag symptoms, stroke/TIA considerations, and recommended initial workup.

Draft an assessment and plan for stage-2 hypertension (BP 162/98) in an obese 52-year-old with suspected obstructive sleep apnea; include ASCVD risk estimate, lifestyle prescriptions, first-line pharmacotherapy with drug/dose/targets, baseline labs/monitoring, and 4–6 week follow-up.

Draft an assessment and plan for type 2 diabetes follow-up with A1c 9.2% on metformin 1,000 mg BID and eGFR 65; compare adding a GLP-1 receptor agonist vs an SGLT2 inhibitor, address weight loss goals, hypoglycemia education, vaccinations, and micro/macrovascular screening.

Draft a history and physical for a patient presenting with chest pain, including HPI using OLDCARTS, pertinent ROS, PMH/meds/allergies, FH/SH, focused cardiac/pulmonary exam, initial labs and imaging orders, prioritized differential, HEART score risk stratification, and early management.

Draft a history and physical for a new patient with progressive exertional dyspnea, orthopnea, and bilateral leg edema; include differential (heart failure, COPD, PE, anemia, renal disease), targeted exam maneuvers, and first-line diagnostics and management.

Draft a progress note for COPD follow-up two weeks after an acute exacerbation treated with prednisone and antibiotics; include symptom trajectory, CAT score (if available), inhaler technique/adherence, oxygen needs, spirometry plan, smoking cessation counseling, and return precautions.

Draft a progress note for post-operative day 2 after total knee arthroplasty; include pain control strategy, DVT prophylaxis, PT/OT milestones, wound status, bowel/urinary function, labs/vitals review, complications screening, and discharge readiness.

Draft a discharge summary for community-acquired pneumonia admission; include admission/discharge dates, presenting symptoms, radiology/labs, pathogen if identified, inpatient therapies and response, discharge medications with durations, pending tests, follow-up appointments, and return precautions.

Draft a discharge summary for myocardial infarction managed with PCI and drug-eluting stent placement; include cath findings, complications, inpatient course, discharge medications (DAPT, statin, beta-blocker, ACEi/ARB), cardiac rehab referral, and follow-up plan.

Draft discharge instructions for a patient hospitalized with acute decompensated heart failure; include daily weights, sodium and fluid restriction amounts, medication list with dosing, signs of worsening heart failure, follow-up appointments, and lab monitoring plan.

Draft discharge instructions for an asthma exacerbation; include controller and reliever regimen, steroid taper schedule, spacer technique, trigger avoidance, a written asthma action plan, return precautions, and follow-up timing.

Draft a patient handout on managing high blood pressure in plain language; explain what BP numbers mean, key lifestyle steps (DASH diet, sodium limits, alcohol moderation), home BP monitoring instructions, medication adherence tips, and when to call the doctor.

Draft a patient handout for type 2 diabetes education in plain language; cover A1c goals, the plate method, physical activity targets, self-monitoring of blood glucose, hypoglycemia signs and the 15-15 rule, foot care basics, and a vaccination checklist.

Draft a summary of the latest CDC and WHO guidelines for managing community-acquired pneumonia in adults, including empiric antibiotic choices, duration of therapy, and follow-up recommendations.

Draft a plain-language overview of the ADA and AACE guidelines for diabetes management, focusing on A1c goals, weight management, and the use of GLP-1 receptor agonists and SGLT2 inhibitors.

Draft a summary of the 2024 USPSTF breast cancer screening recommendations, including updated screening intervals, risk-based approaches, and the role of MRI for high-risk patients.

Draft a concise summary of NCCN guidelines for melanoma management, including staging, surgical margins, adjuvant therapy, and checkpoint inhibitor recommendations.

Draft treatment alternatives for community-acquired MRSA skin infections in patients allergic to sulfa drugs; include oral and IV options, dosing, and duration.

Draft treatment alternatives for patients with type 2 diabetes who are unable to tolerate GLP-1 receptor agonists due to nausea; include medication substitutions and lifestyle recommendations.

Draft a summary of options for treating refractory depression, comparing ketamine infusions, transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT).

Draft treatment options for advanced prostate cancer, including hormonal therapy, radiopharmaceuticals, and novel androgen receptor pathway inhibitors.

Draft a summary of recent research on mRNA vaccine technology beyond COVID-19, including applications in oncology and autoimmune disease prevention.

Draft an easy-to-understand overview of long COVID research, summarizing major symptoms, hypothesized mechanisms, and emerging treatment approaches.

Draft a summary of current research on Alzheimer’s disease biomarkers, including amyloid and tau imaging, and discuss how they influence diagnosis and trial design.

Draft an explanation of the interaction between warfarin and antibiotics such as ciprofloxacin or TMP-SMX, including INR effects and management recommendations.

Draft a summary evaluating drug interactions for patients taking Paxlovid and common cardiovascular drugs; include mechanism and recommended dose adjustments.

Draft a summary of the common and serious side effects of semaglutide, including GI intolerance, gallbladder disease, and thyroid-related warnings.

Draft an overview of potential side effects associated with long-term corticosteroid use, including osteoporosis, glucose intolerance, and adrenal suppression.

Draft a summary of essential lab tests to order in suspected acute pancreatitis, including amylase, lipase, liver enzymes, and metabolic panels, with interpretation guidance.

Draft laboratory workup recommendations for suspected hypothyroidism, including TSH, free T4, thyroid antibodies, and when to consider secondary causes.

Draft an explanation of which labs should be monitored in patients receiving methotrexate therapy, including CBC, LFTs, renal function, and frequency of monitoring.

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Research Article: Analysis of influencing factors and paths of social frailty in older adult patients with ischemic stroke: a cross-sectional study

Date Published: 2025-10-20

Abstract:
Analysis of influencing factors and action pathways of social frailty in older adult patients with ischemic stroke. A cross-sectional study was conducted among older adult inpatients with ischemic stroke in the Department of Neurology of two Grade A tertiary hospitals in Sichuan Province, China, from January to May 2025. Multiple stepwise linear regression analysis was used to analyze the influencing factors of social frailty in older adult patients with ischemic stroke, and structural equation modeling was employed to conduct path analysis on these influencing factors. A total of 437 older adult patients with ischemic stroke completed the study. The prevalence of social frailty in older adult ischemic stroke patients was 38%. Regression analysis showed that activities of daily living, sleep quality, depression, social support, employee medical insurance, language function impairment and stroke recurrence are influencing factors of social frailty levels in older adult patients with ischemic stroke ( p <?0.05). The structural equation model revealed that in the biological dimension, the direct effect of ADL on social frailty was significant ( ? =??0.154, p =?0.002), accounting for 16% of the total direct effects, while its indirect effect through social support was also significant ( ? =??0.061, p =?0.003, 95% CI: ?0.114 to ?0.019), representing 28% of the total effect in the ADL-social frailty pathway; the direct effect of sleep quality on social frailty ( ? =?0.057, p =?0.282) and the indirect effect via social support ( ? =?0.014, p =?0.546, 95% CI: ?0.032 to 0.062) were not significant. In the psychological dimension, depression had a significant direct effect on social frailty ( ? =?0.390, p <?0.001), accounting for 40% of the total direct effects, along with a significant indirect effect via social support ( ? =?0.113, p <?0.001, 95% CI: 0.063–0.181), representing 22% of the total effect in the depression-social frailty pathway. In the social dimension, social support showed a significant direct effect on social frailty ( ? =??0.373, p <?0.001), representing 38% of the total direct effects. This study found that the prevalence of social frailty in older adult patients with ischemic stroke was 38%, and it is closely associated with health insurance type, stroke recurrence, language function, activities of daily living, depression, and social support. These findings provide a reference for clinical practitioners to design targeted interventions.

Introduction:
According to the Global Burden of Disease, Injuries, and Risk Factors Study, stroke is the third leading cause of death globally and ranks fourth in terms of disability-adjusted life years (DALYs), with ischemic stroke accounting for 65.3% of all stroke cases ( 1 ). In China, despite the implementation of nationwide screening and intervention programs targeting high-risk populations, ischemic stroke remains highly prevalent, with both its incidence and prevalence continuing to rise ( 2 ). Aging is a major…

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