Research Article: Prevalence and associated factors of vitamin B12 deficiency among Vietnamese patients with type 2 diabetes receiving metformin therapy: a cross-sectional study
Abstract:
This study examined serum vitamin B12 status and associated clinical factors among Vietnamese patients with type 2 diabetes mellitus (T2DM) receiving metformin.
This hospital-based cross-sectional study included 400 eligible patients treated with metformin for at least 6 months and recruited by non-probability convenience sampling at two hospitals in Thai Binh, Vietnam. The study-defined outcome was serum vitamin B12 <300 pg/mL, comprising absolute deficiency (<200 pg/mL) and marginal status (200 to <300 pg/mL). Associations were examined using univariable analysis and the reported exploratory multivariable logistic regression model.
Overall, 103 participants (25.75%) met the combined threshold: 29 (7.25%) had absolute deficiency and 74 (18.50%) had marginal status. In the reported adjusted model, metformin use >5 years (adjusted odds ratio [AOR] = 1.84; 95% confidence interval [CI]: 1.07-3.18) and anemia (AOR = 3.43; 95% CI: 1.62-7.23) were associated with the outcome. The macrocytosis estimate was highly imprecise.
Low serum vitamin B12 was common in this hospital-based sample. Periodic assessment merits consideration during prolonged metformin therapy, with use >5 years serving as a pragmatic prompt rather than a validated testing threshold. Unexplained anemia or neuropathic symptoms warrant assessment when deficiency is suspected, regardless of treatment duration. The adjusted findings remain exploratory and do not establish causality or model robustness.
Introduction:
This study examined serum vitamin B12 status and associated clinical factors among Vietnamese patients with type 2 diabetes mellitus (T2DM) receiving metformin.
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