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Research Articles Search

Showing 1,040 of 147,163 result(s)
Use of a digital rescue inhaler and at-home spirometer among inner-city children with asthma: a real-world experience

Abstract: Across all age groups, asthma disproportionally affects inner-city underserved populations. Studies on the use of at-home spirometry and digital inhalers have limited…

Date: 2025-10-01

Humoral response induced after intranasal vaccination with heat inactivated Acinetobacter baumannii protects immunodeficient mice against hypervirulent LAC-4 strain

Abstract: Acinetobacter baumannii is an opportunistic bacterium that causes serious nosocomial infections, including pneumonia and bacteremia, especially in immunocompromised…

Date: 2025-10-01

Sex-dependent modulation of acute respiratory distress syndrome by Bacteroides acidifaciens : gut microbiome impact on lung inflammation

Abstract: Bacteroides acidifaciens (BA), a common gut commensal, is known to modulate immune responses, but its role in acute respiratory distress syndrome (ARDS) and potential…

Date: 2025-10-01

Preclinical in vivo evaluation of a gonococcal multivalent vaccine containing antigens identified by CASS

Abstract: Neisseria gonorrhoeae , causative agent of the human sexually transmitted infection gonorrhea, is a significant global health concern because of increasing antimicrobial…

Date: 2025-10-01

Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth

Abstract: RAB7, encoded by RAB7A in humans and Rab7 in mice, is a small GTPase that catalyzes endosome maturation. It mediates NF-?B activation through the assembly of…

Date: 2025-10-01

Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response

Abstract: Pregnancy is a complex process that requires a tightly regulated immune environment to support fetal development and protect against infections. The main barrier between…

Date: 2025-10-01

Antiviral and immunomodulatory effect of zapnometinib in animal models and hospitalized COVID-19 patients

Abstract: In severe COVID-19, direct-acting antiviral drugs were not effective in hyperinflammatory stages and steroid treatment may weaken host immunity. The MEK inhibitor…

Date: 2025-10-01

Heterologous prime-pull mucosal vaccination with an adjuvanted RBD vaccine elicits robust IgA production and protects against SARS-CoV-2

Abstract: Despite the efficacy of approved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing severe disease and death, breakthrough infections…

Date: 2025-10-01

Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells

Abstract: T-cell activation is a highly regulated process requiring both antigen recognition via the T-cell receptor (TCR) and co-stimulatory signaling, notably through the…

Date: 2025-10-01

Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice

Abstract: Heterologous prime–boost vaccination has emerged as a promising approach to enhance immune responses by combining vaccines with complementary mechanisms of antigen…

Date: 2025-10-01