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The contribution of a person-centred model of Lean Six Sigma to the development of a healthful culture of health systems improvement

Abstract: A failure to distinguish between person-centredness, person-centred care, and person-centred cultures can result in improvement initiatives focusing solely on…

Date: 2025-08-18

Association of obesity-related anthropometric indicators with chronic constipation and diarrhea among U.S. adults: a cross-sectional study

Abstract: Prior studies have linked obesity indicators to constipation/diarrhea, but multi-measure comparisons remain limited. We analyzed these associations in U.S. adults. This…

Date: 2025-08-18

From gut to proteomics: the impact of Roseburia intestinalis on post-translational modifications in colorectal cancer

Abstract: Colorectal cancer (CRC) represents a significant global health challenge. Gut microbiota imbalance and abnormal chromatin modifications play critical roles in the…

Date: 2025-08-18

FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2

Abstract: Fatty acid synthase (FASN) is a key regulator of lipid metabolism, but its role in colorectal cancer (CRC) stemness and ferroptosis remains unclear. FASN expression in…

Date: 2025-08-18

Value of a BRAF V600E and lymphocyte subset-based nomogram for discriminating benign lesions from papillary thyroid carcinoma in C-TIRADS 3 and higher nodules

Abstract: The BRAF V600E mutation and lymphocyte subsets may be associated with papillary thyroid carcinoma (PTC). This study established and validated a nomogram model to…

Date: 2025-08-15

Expression levels of T cell-related immune factors and their correlation with thyroid function in Graves’ disease with varied serum iodine status: insights into immunopathogenesis

Abstract: Measurement of Serum Iodine Concentration (SIC) in Newly Diagnosed Adult Graves’ Disease (GD) Patients with Hyperthyroidism and Healthy Controls: Investigating Cytokine…

Date: 2025-08-15

Development of a transtheoretical model for the prevention and treatment of skin disease through ultraviolet protection based on 14,681 samples of outpatient clinics and a cross-sectional survey

Abstract: Little is known about the association between types of skin and subcutaneous diseases and UV protection literacy. To assess the burden and treatment of skin diseases in…

Date: 2025-08-15

The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels

Abstract: Hypertensive disorders in pregnancy (HDP) are associated with an increased risk of neonatal complications; however, their effects on neonatal metabolism remain…

Date: 2025-08-15

An exploratory single-cell analysis of peripheral blood mononuclear cells from vedolizumab-treated Crohn’s disease patients identifies response-associated differences among the plasmacytoid dendritic cells and classical monocytes

Abstract: Vedolizumab (VDZ) is a monoclonal antibody approved for the treatment of Crohn’s disease (CD). Despite its efficacy, non-response to VDZ is common in clinical practice…

Date: 2025-08-15

Lipoprotein combine index is associated with non-alcoholic fatty liver disease: a 5-year longitudinal cohort study in non-obese Chinese populations with normal lipids

Abstract: Current evidence concerning the association between lipoprotein combine index (LCI) and Non-alcoholic fatty liver disease (NAFLD) in non-obese people remains limited.…

Date: 2025-08-15