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Estimating time since influenza virus exposure using single-cell proteomic data

Abstract: Determining when the onset of a respiratory infection occurred is important for effective clinical management and can aid in mapping transmission events. However,…

Date: 2026-03-19

B-type natriuretic peptide attenuates TLR-induced cytokine and chemokine secretion in monocyte-derived Langerhans cells

Abstract: B-type natriuretic peptide (BNP) is a well-known cardiac hormone and biomarker of heart failure, but emerging evidence suggests that it also possesses immunomodulatory…

Date: 2026-03-19

Developing a new assessment model for systemic lupus erythematosus disease activity based on a case cohort

Abstract: To develop and validate a novel SLE disease activity scoring model designed to enhance diagnostic capability for moderate-to-severe disease activity in SLE patients…

Date: 2026-03-19

Morphology-based cytogenetic risk prediction in multiple myeloma from bone marrow smears

Abstract: Cytogenetic abnormalities determine prognosis and treatment selection in multiple myeloma (MM). However, genetic testing via fluorescence in situ hybridization remains…

Date: 2026-03-18

Single-cell sequencing reveals dynamic immune features of paraneoplastic pemphigus in a patient with follicular lymphoma

Abstract: Paraneoplastic pemphigus (PNP) is a highly fatal autoimmune blistering disease that commonly occurs in patients with underlying benign or malignant neoplasms. It poses…

Date: 2026-03-18

Cardiorenal risk stratification in high-risk type 2 diabetes using a simple clinical score: findings from the ELIXA trial

Abstract: Early identification of patients with high cardiorenal risk and timely targeted interventions are critical in managing type 2 diabetes (T2D). Although we previously…

Date: 2026-03-18

Impact of testosterone-based gender-affirming hormone therapy on toll-like receptor transcript levels and peripheral blood leukocyte counts in transmasculine individuals

Abstract: Sex differences in immune responses are partly attributed to sex hormones, with testosterone generally associated with dampened immune responses. However, the specific…

Date: 2026-03-18

Effect of a 5:2 intermittent fasting diet on obese patients with polycystic ovary syndrome

Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects fertility and metabolism. Obesity, present in a significant proportion of PCOS patients,…

Date: 2026-03-18

Effects of gender-affirming hormone therapy from adolescence to adulthood on cardiovascular function: a cross-sectional study

Abstract: Increased cardiovascular risk in transgender adults might be linked in part to metabolic changes associated with gender-affirming hormone therapy (GAHT) and lifestyle…

Date: 2026-03-18

Clinical and economic impacts of a clinical pathway-based single disease payment policy on hysterectomy for uterine fibroids: a decade-long interrupted time series analysis

Abstract: In 2017, China introduced clinical pathway-based single disease payment (CP-SDP) to curb healthcare costs, yet its impact is uncertain. Using uterine fibroids as a case,…

Date: 2026-03-18