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Integrative Mendelian randomization and experimental validation prioritize KLF4 in the gut microbiota–pyroptosis–barrier axis of ulcerative colitis

Abstract: Ulcerative colitis (UC) arises from complex crosstalk between gut microbiota, epithelial barrier integrity, and inflammatory cell death, yet causal mediators along this…

Date: 2026-03-16

SHAP-explained machine-learning model for high-risk gastric cancer identification

Abstract: Gastric cancer (GC) remains a major public health concern in Asia. Risk prediction tailored to regional biological features such as Helicobacter pylori ( H. pylori )…

Date: 2026-03-16

Global research trends in biliary atresia-related liver fibrosis: a bibliometric analysis (2000–2024)

Abstract: Biliary atresia (BA) is a severe neonatal liver disorder that can progress to liver fibrosis and eventual failure. This bibliometric study evaluates global research on…

Date: 2026-03-16

Effects of evidence-based early mobilization on prognostic outcomes in older patients with acute ischemic stroke

Abstract: Early mobilization is a key component of stroke-unit rehabilitation, yet evidence regarding structured, protocolized early mobilization in older adults with acute…

Date: 2026-03-16

Serotype-specific tropism of adeno-associated viruses in dorsal meningeal lymphatic vessels via intra-cisterna magna delivery

Abstract: Meningeal lymphatic vessels (mLVs) in the brain acts as the regulator that eliminates harmful macromolecules in post-cerebrospinal fluid (CSF) and facilitates immune…

Date: 2026-03-16

Switching strategies with CGRP monoclonal antibodies: an observational study in a headache clinic

Abstract: Migraine is a disabling neurological disorder that greatly impacts quality of life and productivity. Calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs)…

Date: 2026-03-16

Influence of interhospital transfer on endovascular thrombectomy outcome in acute ischemic stroke patients: an analysis of the TREAT-AIS registry

Abstract: The outcome of patients undergoing endovascular thrombectomy (EVT) for large vessel occlusion in a comprehensive stroke center (CSC) is affected by the…

Date: 2026-03-16

Headache comorbidity in epilepsy and functional/dissociative seizures: an exploratory cross-sectional study in a tertiary epilepsy center

Abstract: Headache disorders are common in patients with epilepsy and functional/dissociative seizures (FDS) and may influence quality of life and clinical outcomes. Migraine has…

Date: 2026-03-16

Subgroups based on autoantibody status associated with clinical manifestations, HLA-DRB1 variants, cytokines, and flare of vasculitis in childhood-onset systemic lupus erythematosus

Abstract: Childhood-onset systemic lupus erythematosus (cSLE) exhibits significant heterogeneity, leading to challenges in prognosis and treatment. This study aims to stratify…

Date: 2026-03-16

Flexible intubating video endoscope-guided determination of optimal oral endotracheal tube depth in infants: a prospective observational study

Abstract: To assess the accuracy of Advanced Pediatric Life Support (APLS) and Neonatal Resuscitation Program (NRP) formulas for predicting oral endotracheal tube (ETT) depth in…

Date: 2026-03-13