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Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study

Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disorder with poorly defined pathogenic mechanisms. The integrated stress response (ISR), an evolutionarily…

Date: 2026-03-26

Analysis of risk factors for relapse in pediatric MOG antibody-associated disease: a single-center retrospective cohort study

Abstract: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated demyelinating disorder of the central nervous system. It has a higher…

Date: 2026-03-26

Efficacy and safety of adjunctive clobazam in Chinese patients with drug-resistant epilepsy: a single-center real-world study

Abstract: This study evaluated the efficacy and safety of adjunctive clobazam (CLB) in Chinese patients with drug-resistant epilepsy (DRE). We retrospectively included 121 DRE…

Date: 2026-03-26

Additive effect of patient anosognosia and theory of mind deficit on dementia caregiver distress

Abstract: Caregiver distress in dementia is multifactorial. The contribution of disease specific factors including anosognosia (poor awareness of cognitive/behavioral deficits)…

Date: 2026-03-26

The etiological spectrum of pediatric FUO and clinical management of PFAPA/SURF: a ten-year retrospective study

Abstract: This study aimed to define the etiologies and clinical features of pediatric Fever of unknown origin (FUO), focusing on periodic fever, aphthous stomatitis, pharyngitis,…

Date: 2026-03-26

Identification and validation of necroptosis-related genes in peripheral blood mononuclear cells of Sjögren disease

Abstract: Necroptosis has been implicated in multiple inflammatory and autoimmune disorders. However, its role in Sjögren disease (SjD) remains elucidated. In the current study,…

Date: 2026-03-26

A retrospective clinical analysis of pediatric mediastinal space-occupying lesions in a Chinese children’s hospital from 2015 to 2024

Abstract: Pediatric mediastinal space-occupying lesions (MSOLs) encompass a wide spectrum of conditions, including benign and malignant, infectious and reactive, as well as…

Date: 2026-03-25

Development and validation of a prediction model for primary non-response to IL-17A inhibitors in psoriasis

Abstract: Interleukin-17A (IL-17A) inhibitors have revolutionized the treatment of moderate-to-severe plaque psoriasis, but a substantial proportion of patients experience primary…

Date: 2026-03-25

Re-evaluating early high-frequency oscillatory ventilation in moderate-to-severe pediatric ARDS: evidence from a genetic matching analysis

Abstract: Pediatric acute respiratory distress syndrome (PARDS) carries high mortality in pediatric intensive care units (PICUs). The clinical benefit of early high-frequency…

Date: 2026-03-25

Risk factors for necrotizing enterocolitis in preterm infants: a 1:1 matched case-control study

Abstract: This study demonstrates that neonatal sepsis, blood transfusion, combined antibiotic use, asphyxia, and maternal gestational diabetes (GDM) are independent risk factors…

Date: 2026-03-25