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Dapagliflozin lowers blood pressure via regulating the sympathetic neural activity in the paraventricular nucleus of hypothalamus in normal mice

Abstract: The risk of heart failure (HF) is significantly higher in patients with type 2 diabetes mellitus (T2DM). Recent studies have shown that an imbalance in the sympathetic…

Date: 2026-01-23

Single-cell transcriptomics reveals keratinocyte dynamic processes associated with S100a4 expression in psoriasiform dermatitis

Abstract: Psoriasis is a common autoimmune skin disease with high morbidity and associated complications, characterized by epidermal hyperplasia and cutaneous infiltration of…

Date: 2026-01-23

Gut mycobiota dysbiosis and an emergent state of “co-dysbiosis” are associated with IgE sensitization in children with comorbid allergic rhinitis and constipation

Abstract: The comorbidity of allergic rhinitis (AR) and functional constipation (FC), termed ARFC, implies shared gut–immune pathways. Although bacterial dysbiosis has been…

Date: 2026-01-23

Specific IgE to tropomyosin increases the diagnostic accuracy of shrimp allergy

Abstract: Skin prick test (SPT) and the level of serum-specific IgE (sIgE) antibodies to shrimp have low specificity in the diagnosis of shrimp allergy. Measurement of sIgE to…

Date: 2026-01-23

Exploring the level of knowledge related to ectopic pregnancy among married Saudi women

Abstract: Ectopic pregnancy (EP) is an abnormal condition in which blastocyst implantation occurs outside the lining of the uterus and is the leading cause of pregnancy-related…

Date: 2026-01-23

Pregnancy outcomes of patients with retained products of conception following miscarriage treated with relugolix, an oral gonadotropin-releasing hormone antagonist

Abstract: Relugolix, an oral gonadotropin-releasing hormone (GnRH) antagonist, represents a potentially effective and less invasive therapeutic approach for retained products of…

Date: 2026-01-23

Impact of advanced paternal age on reproductive outcomes in preimplantation genetic testing cycles of young female: a retrospective cohort study

Abstract: Although advanced paternal age (APA) is increasingly scrutinized in reproductive medicine, its independent impact on embryo development and clinical outcomes remains…

Date: 2026-01-23

Maternal mixed UPD3 and a homozygous PLXNA1 c.2497G>C variant in a fetus with severe anomalies

Abstract: Non-invasive prenatal testing (NIPT) is widely used for screening common fetal aneuploidies such as trisomy 21 (T21), trisomy 18 (T18), and trisomy 13 (T13). However,…

Date: 2026-01-23

Young males in crisis: pathways, usage and acceptability of an online messenger based psychosocial counselling service

Abstract: Boys and young men face an elevated risk of mental health problems and suicidality, yet they remain less likely than their female peers to seek professional help. Online…

Date: 2026-01-23

Two-injection start regimen of long-acting aripiprazole for bipolar disorder: tips and tricks for better efficacy and tolerability

Abstract: To comparatively evaluate the efficacy and safety of the two aripiprazole long-acting injectable (LAI) initiation regimens, including one-injection start (OIS) regimen…

Date: 2026-01-23