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Integration of single-cell sequencing, transcriptome sequencing, and machine learning for constructing and validating histone acetylation-related prognostic risk models in hepatocellular carcinoma

Abstract: Liver hepatocellular carcinoma (LIHC), a prevalent gastrointestinal malignancy, continues to demonstrate poor prognosis despite therapeutic advances improving clinical…

Date: 2026-01-23

Dinutuximab beta versus historical controls in the treatment of relapsed neuroblastoma: unadjusted and adjusted indirect comparisons

Abstract: Dinutuximab beta (dB) immunotherapy is used as maintenance treatment for relapsed/refractory neuroblastoma (NBL); however, comparative studies directly comparing dB with…

Date: 2026-01-22

Circulating thyroid hormones and metabolites in children with autism spectrum disorder

Abstract: Thyroid hormones affect neurological development and function, but detailed studies of thyroid hormones and metabolites in autism are lacking. To characterize thyroid…

Date: 2026-01-22

Factors influencing treatment duration of oral propranolol in infantile hemangioma: a five-year retrospective analysis

Abstract: Oral propranolol is effective in promoting the involution of infantile hemangiomas (IHs), but treatment outcomes vary widely. To identify demographic and clinical…

Date: 2026-01-22

Perinatal outcomes in neonates referred to social services in a tertiary neonatal intensive care unit from a resource-limited setting: a five-year study

Abstract: Beyond medical complexity, social determinants of health and social vulnerability have emerged as factors shaping perinatal and neonatal outcomes among socially…

Date: 2026-01-22

Pre-injection of saline on the anterior scalene muscle reduced brachial plexus nerve block-induced hemidiaphragmatic paralysis

Abstract: This study aimed to evaluate the effect of pre-injecting normal saline over the anterior scalene muscle (ASM) on the incidence of hemidiaphragmatic paralysis (HDP)…

Date: 2026-01-22

Direct and indirect effects of physical exercise on life satisfaction and quality of life in Chinese adolescents during the COVID-19 pandemic

Abstract: The COVID-19 pandemic exacerbated mental health challenges among adolescents, yet the protective role of regular physical exercise (PE) in enhancing life satisfaction…

Date: 2026-01-22

Sex differences in cognitive function among patients with bipolar disorder

Abstract: Bipolar disorder (BD) is a severe mental illness characterized by high recurrence rates and notable cognitive deficits. Although sex differences are known to influence…

Date: 2026-01-22

Integrated analysis of risk factors, visual prognosis, and pathogens in pediatric post-traumatic endophthalmitis: a retrospective cohort study

Abstract: Research on pediatric ocular trauma remains limited, and clinical management is often extrapolated from adult data. This study aimed to analyze the risk factors, visual…

Date: 2026-01-22

Relationship between lacrimal gland changes and corneal parameters in patients with primary Sjögren’s syndrome and non-Sjögren’s syndrome-related dry eye

Abstract: Primary Sjögren’s syndrome(pSS) is characterized as an autoimmune disorder mostly involving exocrine glands and pSS related dry eye (SSDE) contributes to a severe…

Date: 2026-01-22