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Temporal dynamics of cisplatin-induced endothelial senescence and its association with cognitive impairment: insights into the medial prefrontal cortex

Abstract: Chemotherapy-related cognitive impairment (CRCI) poses significant challenges for cancer survivors, with its underlying mechanisms remaining inadequately understood,…

Date: 2025-10-28

The prognostic significance of incomplete hematological recovery in pediatric patients with low/intermediate risk AML and negative MRD after induction 1

Abstract: Pediatric acute myeloid leukemia (AML) accounts for approximately 25% of childhood hematologic malignancies. Outcomes have markedly improved, especially in low-risk and…

Date: 2025-10-28

Association between inflammation- and nutrition-related indicators and mortality in patients with heart failure: a cohort study

Abstract: Inflammation and malnutrition are critical in heart failure (HF) progression. This study evaluated the prognostic value of inflammation- and nutrition-related indicators…

Date: 2025-10-28

Neuroendoscopic hematoma evacuation vs. craniotomy in hypertensive intracerebral hemorrhage: a retrospective comparative study on surgical efficiency and long-term functional outcomes

Abstract: To investigate the impact of neuroendoscopic surgery on surgical efficiency and long-term functional outcomes in patients with hypertensive intracerebral hemorrhage…

Date: 2025-10-27

Novel insights and clinical perception of the patients with acute leukemia transferred to ICU: a multi-center retrospective study spanning 10?years

Abstract: Intensive care unit (ICU) is a professional and special ward for the treatment of various critical and severe diseases in clinical medical institutions, which is an…

Date: 2025-10-27

MiR-668-5p targets ZNRF3, an E3 ubiquitin ligase to enhance osteoblast function and alleviate senescence in doxorubicin-induced age-related bone loss

Abstract: Aging is a complex biological phenomenon that drives the progression of numerous chronic conditions, including osteoporosis, which is characterized by bone loss and…

Date: 2025-10-27

Bilateral breast nodules as an unusual manifestation of 17?-hydroxylase/17,20-lyase deficiency

Abstract: 17?-hydroxylase/17,20-lyase deficiency (17-OHD) typically presents with sexual infantilism, hypertension, and hypokalemia. However, phenotypic variability, particularly…

Date: 2025-10-27

The relationship between copper intake and chronic kidney disease/diabetic kidney disease: insights from NHANES data (2011-2018)

Abstract: The connection between copper consumption and chronic kidney disease (CKD), as well as diabetic kidney disease (DKD), is still unclear. This research seeks to explore…

Date: 2025-10-27

Diagnostic performance of a radiological Fagotti score assessed on diffusion-weighted magnetic resonance imaging for predicting tumor resectability in ovarian cancer patients: a feasibility study

Abstract: In ovarian cancer, the correct selection of patients for cytoreductive surgery is of great importance. The aim of this study was to evaluate the diagnostic performance…

Date: 2025-10-27

Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis

Abstract: The causal role of cellular senescence in preeclampsia pathogenesis is not fully established. This study aimed to systematically prioritize key senescence-related genes…

Date: 2025-10-27