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High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

Abstract: Single-cell RNA sequencing (scRNA-seq) enables high-resolution profiling of immune heterogeneity. Although previous studies have mapped the single-cell transcriptomic…

Date: 2025-12-18

Machine learning and validation reveal that immune-related genes in systemic lupus erythematosus regulate apoptosis and cycle progression in diffuse large B-cell lymphoma

Abstract: Systemic lupus erythematosus (SLE) and diffuse large B-cell lymphoma (DLBCL) are both characterized by immune dysregulation. SLE has been reported as a risk factor for…

Date: 2025-12-18

Early intrathecal dexamethasone and methotrexate as an effective approach for immune effector cell-associated neurotoxicity syndrome after CAR-T cell therapies

Abstract: Chimeric antigen receptor T (CAR-T) cell therapies have demonstrated remarkable success in treating relapsed and refractory (R/R) B-cell hematological malignancies.…

Date: 2025-12-17

Immuno-protective impact of Kangfuxin liquid on systematic toxicity associated with autologous hematopoietic stem cell transplantation in multiple myeloma

Abstract: This study evaluated the effectiveness of Kangfuxin liquid against autologous stem cell transplantation toxicity in patients with multiple myeloma. This single-center…

Date: 2025-12-17

Optical coherence tomography and electroretinography in pituitary macroadenomas: a 12-month analysis by age and tumor type

Abstract: To evaluate longitudinal changes in optical coherence tomography (OCT) and electroretinography (ERG) parameters over 12 months in patients with pituitary macroadenomas,…

Date: 2025-12-17

Levothyroxine dose prediction post-thyroidectomy for differentiated thyroid carcinoma

Abstract: To address the overestimation of levothyroxine (L-T4) doses in conventional weight-based regimens for individuals who are overweight and obese, this study aimed to…

Date: 2025-12-17

Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients

Abstract: The prognosis of patients with cancer in which tumor-associated macrophages with a pro-tumoral phenotype are abundant is poor. This includes aggressive forms of…

Date: 2025-12-17

Development of the pruritus-associated stress scale: a cross-sectional pilot study

Abstract: A significant relationship exists between perceived stress and the exacerbation and perpetuation of chronic pruritic dermatoses. Despite this, there is a notable absence…

Date: 2025-12-17

Global, regional, and national burdens of pruritus in children and adolescents aged under 20?years from 1990 to 2021: a trend analysis

Abstract: This study aims to analyze the global pruritus burden and trend among children and adolescents aged under 20 from 1990 to 2021 based on the existing Global Burden of…

Date: 2025-12-17

Psychosocial functioning in children with a congenital heart disease: attachment and emotion regulation strategies of children and parents as explanatory factors

Abstract: Children born with congenital heart disease (CHD) face increased risk of psychosocial difficulties. These may stem from challenges in parent–child relationships and…

Date: 2025-12-17