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Polysialic acid restrains inflammatory monocyte maturation

Abstract: Sialic acids are widely distributed monosaccharides in the central nervous system (CNS), where they are predominantly found as terminal sialic acid residues, as well as…

Date: 2025-10-20

Deep medullary veins disruption in cerebral small vessel disease: links to AI-quantified lesions and cognitive decline

Abstract: The relationship between cerebral small vessel diseases (CSVD) and deep medullary veins (DMV) has been the subject of only a limited number of studies to date, with the…

Date: 2025-10-20

Efficacy and safety of idebenone tablets in patients with post-stroke cognitive impairment: a real-world study

Abstract: To evaluate the efficacy, safety, and adherence of idebenone tablets in improving cognitive function among patients with post-stroke cognitive impairment in a real-world…

Date: 2025-10-20

Individualized psychotherapy reveals a very high prevalence of adverse life events in functional neurological disorders

Abstract: Adverse life events are frequent in patients with functional neurological disorder (FND), although their prevalence is highly variable when assessed using standardized…

Date: 2025-10-20

Plasma branched-chain amino acids and risk of radiation-induced acute skin toxicity in women with breast cancer: results from the ATHENA project

Abstract: Little is known regarding the influence of circulating plasma branched-chain amino acids (BCAAs) such as leucine, isoleucine, and valine on acute skin toxicity (AST)…

Date: 2025-10-20

Differential diagnosis of eczema and psoriasis using routine clinical data and machine learning: development of a web-based tool in a multicenter outpatient cohort

Abstract: Eczema and psoriasis are common chronic dermatoses with overlapping features, making early differential diagnosis difficult. While biopsy is the gold standard, its…

Date: 2025-10-17

Psoriasis vulgaris leaves a dynamic imprint on circulating and skin ?? TCR repertoires shaped by disease severity, age, and sex

Abstract: Psoriasis vulgaris (PV) is a common, T cell mediated dermatosis with substantial systemic footprint. While ?? T cells are well established drivers of PV, the role of ??…

Date: 2025-10-17

Association of serum bicarbonate with 28-day and 90-day mortality in patients with epilepsy and concurrent sepsis: a retrospective cohort study

Abstract: Serum bicarbonate concentration is a predictor of adverse outcomes in various diseases. However, its role in forecasting outcomes specifically for patients with epilepsy…

Date: 2025-10-17

Expert consensus on fetal ventriculomegaly: evidence-based recommendations for 23 key clinical questions

Abstract: Fetal ventriculomegaly (VM), defined as an atrial diameter ?10?mm, is one of the most frequently identified central nervous system anomalies on prenatal imaging. This…

Date: 2025-10-17

Gait and frontal lobe function become associated in patients with idiopathic normal pressure hydrocephalus after shunt surgery

Abstract: The association between gait and cognition in older adults is well-established. This study investigated the association between gait and cognition, especially in the…

Date: 2025-10-17