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Correlation of immune cell subsets in the tumor microenvironment and peripheral blood with immunotherapy response in esophageal squamous cell carcinoma

Abstract: Esophageal squamous cell carcinoma (ESCC) is commonly diagnosed at an advanced stage, where conventional chemoradiotherapy offers only limited clinical benefit. Immune…

Date: 2025-10-17

Machine learning model for predicting epidermal growth factor receptor expression status in breast cancer using ultrasound radiomics

Abstract: The epidermal growth factor receptor (EGFR) is a clinically important target, as its expression in patients with breast cancer influences both overall and disease-free…

Date: 2025-10-17

Modest radiation dose escalation for early-stage anal cancer: cancer control and toxicity outcomes

Abstract: The optimal dose for patients with early-stage squamous cell carcinoma of the anus (SCCA) is unknown. We aimed to evaluate the impact of modest dose escalation (54 Gray…

Date: 2025-10-17

Machine learning-based predictive model for immune checkpoint inhibitors response in gastrointestinal cancers

Abstract: Gastrointestinal (GI) cancers present significant clinical challenges characterized by dismal survival outcomes and suboptimal prognoses. Currently, only partial…

Date: 2025-10-17

A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry

Abstract: Antiphospholipid syndrome (APS) is an autoimmune disease with thromboembolic and obstetric morbidity arising via a model of immunothrombosis. Individuals with APS may…

Date: 2025-10-16

B7-H7 knockdown suppresses the proliferation, metastasis, and drug resistance of B-cell non-Hodgkin lymphoma cells by inhibiting the PI3K/Akt pathway

Abstract: The activation of key immune regulatory factors is an important driving factor in the progression of therapeutic resistance in patients with B-NHL. As a novel immune…

Date: 2025-10-16

Systemic immune inflammation index guides machine learning for rapid TTP diagnosis: a retrospective cohort study

Abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare, life threatening thrombotic microangiopathy that requires prompt diagnosis to reduce mortality. However, its early…

Date: 2025-10-16

The exploration of using plasma biomarkers of p-tau217 and p-tau181 for screening Alzheimer’s disease in very elderly people

Abstract: Blood-based biomarkers for Alzheimer’s disease (AD), such as phosphorylated tau (p-tau181, p-tau217) and amyloid beta (A?), have the potential to serve as screening…

Date: 2025-10-16

Toward precision psychiatry: theoretical implications of bimodal response patterns to vasopressin V1b receptor inhibition in depression

Abstract: Despite extensive research and numerous available treatments, major depressive disorder (MDD) remains a significant global health issue with limited efficacy from…

Date: 2025-10-16

ATF3 prevents retinal ganglion cell apoptosis and mitigates microglia-mediated neuroinflammation in retinal ischemia–reperfusion injury

Abstract: Neuroinflammation is a key pathological response involved in secondary optic nerve injury following retinal ischemia–reperfusion injury. The expression of activating…

Date: 2025-10-16