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Comparative effectiveness and safety of tenecteplase versus alteplase for intravenous thrombolysis in acute ischemic stroke: a retrospective study

Abstract: Tenecteplase has been proposed as a practical alternative to alteplase for intravenous thrombolysis in acute ischemic stroke. Although randomised trials have…

Date: 2025-10-13

Effect of the EBM-integrated BOPPPS model on clinical competence and EBM confidence in neurology clerkships for three-year junior college medical clerks

Abstract: Neurology clerkships are critical for clerks’ transition from student to assistant physician, but complex neurological content and traditional lecture-based teaching…

Date: 2025-10-13

Net water uptake combined with neutrophil-to-lymphocyte ratio predictive value after successful recanalization in acute large vessel occlusion stroke

Abstract: Despite successful recanalization after endovascular thrombectomy (EVT), some patients with acute large vessel occlusion stroke (ALVOS) have poor clinical outcomes. This…

Date: 2025-10-13

Mediation analysis for integrating motor symptoms of Parkinson’s disease, cognitive function, and gait characteristics

Abstract: In Parkinson’s disease (PD) patients, the severity of motor symptoms is closely related to the degree of gait disorder and cognitive impairment; notably, the latter also…

Date: 2025-10-13

The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies

Abstract: Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear,…

Date: 2025-10-13

Adipose tissue IL-23 is associated with fasting blood glucose and HbA1c in overweight/obese individuals

Abstract: IL-23, a proinflammatory cytokine, plays a role in the development of inflammatory diseases. However, the association between IL-23 expression in adipose tissue (AT) and…

Date: 2025-10-13

Real-world study of adebrelimab as first-line therapy for extensive-stage small cell lung cancer: a retrospective study

Abstract: Extensive-stage small cell lung cancer (ES-SCLC) has a poor prognosis, with historical median overall survival (OS) of 8–13 months under platinum-etoposide chemotherapy.…

Date: 2025-10-13

Multi-omics profiling reveals the role of 4-ethylbenzoic acid in promoting proliferation and invasion of cervical cancer

Abstract: Cervical cancer (CC) is a global health challenge, ranking fourth among cancers in women. Microbiome–metabolome interactions influence human papillomavirus (HPV)…

Date: 2025-10-13

Association of white blood cell count to hemoglobin ratio with the life quality after laparoscopic surgery in patients with endometriosis

Abstract: Endometriosis (EM) is a common hormone-dependent and chronic inflammatory disease affecting women of reproductive age, characterized by pelvic pain, infertility, and…

Date: 2025-10-13

Chromosome 11q13 amplification as a decision-making biomarker for anti-PD-1 immunotherapy in recurrent or metastatic head and neck squamous cell carcinoma: a prospective cohort study

Abstract: Anti-programmed cell death protein 1 (anti-PD-1) immunotherapy has shown efficacy in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), but…

Date: 2025-10-13