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Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma

Abstract: Lung adenocarcinoma is the most prevalent lung cancer type, with a 5-year survival rate for advanced patients below 20%. This study aims to develop a risk model to guide…

Date: 2025-09-29

Comparison of efficacy and side effects between short-course radiotherapy and chemotherapy with or without immunotherapy in the neoadjuvant treatment for patients with locally advanced rectal cancer

Abstract: To evaluate the efficacy and safety of short-course radiotherapy (SCRT) combined with chemotherapy (ChT) with or without immunotherapy (IT) in the neoadjuvant treatment…

Date: 2025-09-29

Strategy to select nasopharyngeal cancer patients for adaptive radiotherapy

Abstract: Nasopharyngeal cancer (NPC) patients experience significant anatomical changes during radiation treatment (RT). Adaptive radiotherapy (ART) can be initiated in response…

Date: 2025-09-29

Association between ambient air pollution and outpatient visits for primary acquired lacrimal duct obstruction in Hangzhou, China

Abstract: Primary acquired lacrimal duct obstruction (PALDO) is the most common lacrimal drainage disease in clinics, which can be caused by multiple factors. However, few studies…

Date: 2025-09-29

PD-L1 expression in cerebrospinal fluid for leptomeningeal metastasis from solid tumors: preliminary assessment of clinical implications

Abstract: Intrathecal immune checkpoint inhibitors have shown promise for leptomeningeal metastasis (LM). Programmed cell death ligand 1 (PD-L1) is currently the primary…

Date: 2025-09-29

Real-world disproportionality analysis of cardiac failure associated with novel antineoplastic agents in breast cancer: a pharmacovigilance study

Abstract: Some antineoplastic agents have been implicated in cardiac failure (CF), but large-scale real-world data remain limited. This study aimed to assess disproportional…

Date: 2025-09-29

Dosimetric evaluations using cycle-consistent generative adversarial network synthetic CT for MR-guided adaptive radiation therapy

Abstract: Magnetic resonance (MR) guided radiation therapy combines high-resolution image capabilities of MRI with the precise targeting of radiation therapy. However, MRI does…

Date: 2025-09-29

Herring oil rich in long-chain monounsaturated fatty acid (C22: 1n-11) lowers plasma lipids and modulates fatty acid composition, oxidation, and inflammation in rats

Abstract: Marine oils and fatty fish rich in long-chain n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3,…

Date: 2025-09-26

A real-world data study of the effect of co-solvent differences on the clinical safety of melphalan for injection

Abstract: This study aimed to compare the efficacy and safety of myeloablative conditioning with high-dose propylene glycol-free melphalan (PGF-Mel, EVOMELA ® ) versus propylene…

Date: 2025-09-26

Next-generation sequencing reveals clinical features and prognosis of gene mutations in Chinese children with T-cell acute lymphoblastic leukaemia

Abstract: The 5-year overall survival (OS) for paediatric T-cell acute lymphoblastic leukaemia (T-ALL) exceeds 80% under the current treatment strategies; however, some patients…

Date: 2025-09-26