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Association between anatomical subtypes of medullary infarction and clinical outcome: a multicenter cohort study

Abstract: This multicenter, large-sample retrospective cohort study aimed to investigate the clinical characteristics, early neurological deterioration (END), clinical outcome,…

Date: 2026-03-24

Integrative profiling of lactylation reveals prognostic biomarkers and an immunosuppressive niche in acute myeloid leukemia

Abstract: The overall survival rate of acute myeloid leukemia (AML) remains less than 30%. Metabolic reprogramming of leukemia cells, such as the Warburg effect, enables them to…

Date: 2026-03-23

Symptom severity clusters in myeloproliferative neoplasms are unrelated to disease phenotype: results from a multicenter survey of the East German study group for hematology and oncology (OSHO #97)

Abstract: Myeloproliferative neoplasms (MPNs) comprise a heterogeneous group of clonal hematopoietic stem cell disorders with distinct molecular pathogenesis and treatment…

Date: 2026-03-23

External validation and application of a machine learning–based model for diabetes progression in prediabetes

Abstract: This study externally validated a machine learning–based model for type 2 diabetes progression (ML-PR) and evaluated its clinical utility in individuals with…

Date: 2026-03-23

Hypernatremia secondary to partial urinary tract obstruction: a case report

Abstract: This case report describes a 52-year-old male with a 6-month history of polydipsia and polyuria, and increased urinary foam for 2 months. He was initially diagnosed with…

Date: 2026-03-23

Quality of life in refractory Graves’ hyperthyroidism: a cross-sectional study comparing long-term ATDs therapy versus L-T4 replacement after iodine-131

Abstract: Evaluate and compare the patient-reported quality of life (QoL) outcomes in Graves’ disease patients on long-term antithyroid drugs (ATDs) therapy and levothyroxine…

Date: 2026-03-23

Single-center experience description of surgical management of diffuse congenital hyperinsulinism in a pediatric non-current cohort

Abstract: In this study, we describe surgical indications, procedure selection, and postoperative outcomes in Chinese children with diffuse congenital hyperinsulinism (DCHI).…

Date: 2026-03-23

Thyroid autoantibodies predict long-term treatment response in euthyroid chronic spontaneous urticaria: a retrospective cohort study with propensity score matching

Abstract: Chronic spontaneous urticaria (CSU) affects 0.5–1% of the population, with 40% remaining refractory to guideline-recommended therapy. Thyroid autoantibodies (TPOAb/TgAb)…

Date: 2026-03-23

A cross-sectional examination of immune adaptations during pregnancy in the ECHO Cohort

Abstract: Pregnancy requires finely tuned immune changes that support implantation, placental development, maternal–fetal tolerance, and preparation for labor, yet the normative…

Date: 2026-03-23

Laparoscopic vs. laparotomy tubal recanalization for fertility restoration after tubal sterilization: a retrospective analysis

Abstract: To compare the therapeutic effects of laparoscopic recanalization and laparotomy recanalization on tubal patency restoration after tubal sterilization. A retrospective…

Date: 2026-03-23