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A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response

Abstract: Ulcerative colitis (UC) is a chronic mucosal immune disorder in which 30-50% of patients fail biologic therapy, yet the full-thickness immune architecture of medically…

Date: 2026-09-25

Noninvasive prediction of microvascular invasion in hepatocellular carcinoma using a fusion model of 5-mm optimal peritumoral radiomics and imaging features based on multiphasic gadoxetic acid-enhanced MRI

Abstract: Microvascular invasion (MVI) is a remarkable factor used to predict postoperative recurrence and decide the management plan in patients with hepatocellular carcinoma…

Date: 2026-09-25

Development of a predictive model for pancreatic cancer integrating serum metabolomics and polygenic risk score

Abstract: Pancreatic cancer (PC) is highly aggressive and associated with extremely poor prognosis. Due to the lack of specfic symptoms in the early stage, most patients have…

Date: 2026-09-25

A longitudinal study on the impact of stroke patients’ perception trajectories of disease recurrence on short-term clinical outcomes

Abstract: To investigate heterogeneous trajectories of recurrence risk perception among stroke patients within 6?months after discharge and their correlation with short-term…

Date: 2026-09-25

Phenotypic, functional and metabolic features of B cells from a small cohort of breast cancer patients

Abstract: Identify and characterize breast cancer (BC)-induced changes of humoral immunity and B cell function in a small cohort of treatment-naïve breast cancer patients (BCPs)…

Date: 2026-09-25

Global knowledge structure and thematic evolution in inflammation-associated gastric cancer epigenetics: a multidatabase science-mapping study with nested latent Dirichlet allocation and independent NMF validation

Abstract: Inflammation-associated epigenetic regulation links microbial exposure and chronic mucosal injury to gastric carcinogenesis, immune remodeling, molecular heterogeneity,…

Date: 2026-09-25

Trends and disparities in breast cancer mortality among older adults in the United States, 1999–2020

Abstract: Breast cancer remains a major cause of cancer mortality among older adults in the United States. Although overall breast cancer mortality has declined in recent decades,…

Date: 2026-09-25

CT-based deep learning auto-segmentation of high-risk clinical target volume in CT-guided cervical cancer brachytherapy: a single-center pragmatic study

Abstract: Computed tomography (CT)-based high-risk clinical target volume (HR-CTV) auto-segmentation has been previously investigated, but evidence remains heterogeneous across…

Date: 2026-09-25

Prediction of pathological complete response after neoadjuvant therapy in breast cancer using pretreatment core biopsy pathology reports: a pathology-report-driven model with exploratory clinical-laboratory fusion

Abstract: Pathological complete response (pCR) after neoadjuvant therapy is an important response endpoint in breast cancer. We investigated whether routinely generated…

Date: 2026-09-25

Therapeutic efficacy of recombinant human brain natriuretic peptide in elderly chronic heart failure patients: associations with changes in P?NP and suPAR levels

Abstract: To systematically evaluate the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) added to conventional treatment in elderly patients with chronic…

Date: 2026-09-25