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Changes in drug-use behaviors among people who use drugs with comorbid psychiatric disorders across the COVID-19 pandemic: a three-phase longitudinal cohort study

Abstract: The COVID-19 pandemic substantially affected people who use drugs (PWUD) with comorbid psychiatric disorders. Lockdowns, shifts in drug markets, and fear of infection…

Date: 2026-09-17

Do patients with non-traumatic rotator cuff tears differ from healthy individuals in forward head posture, rounded shoulder posture, and thoracic kyphosis?

Abstract: Altered cervicothoracic and scapular posture may influence shoulder mechanics, but it remains unclear whether patients with non-traumatic rotator cuff tears show…

Date: 2026-09-17

A novel stop-loss variant in ISG15 causes C-terminal dysfunction and impairs USP18-mediated negative feedback

Abstract: ISG15 is a type I interferon (IFN-I)-inducible ubiquitin-like protein that restrains IFN-I signaling. Classical ISG15 deficiency is thought to cause disease mainly by…

Date: 2026-09-17

Disease-specific heterogeneity of C-reactive protein across 21 hematologic disorders reflects divergent inflammatory and hematopoietic phenotypes

Abstract: C-reactive protein (CRP) is routinely used to quantify systemic inflammation, yet its interpretation in hematologic disorders is complicated by marked biological…

Date: 2026-09-17

Cross-modality network phenotyping: a multivariate MRI biomarker signature predicts spatial pathology and clinical severity in EAE

Abstract: Evaluating novel therapies for multiple sclerosis requires robust, non-invasive biomarkers. In the experimental autoimmune encephalomyelitis (EAE) model, standard…

Date: 2026-09-17

Association of tumor mutational burden and tumor-infiltrating lymphocytes with second primary cancer after complete resection of non-small cell lung cancer

Abstract: The risk of developing second primary cancers (SPC) after complete surgical resection of non-small cell lung cancer (NSCLC) has been estimated at 1-2% per patient-year.…

Date: 2026-09-17

Establishment and characterization of patient-derived mucinous gastric cancer organoids with faithful histopathological features and reproducible drug response patterns

Abstract: Mucinous gastric cancer (MGC) is a rare subtype of gastric cancer (GC) characterized by distinct histological features and clinical behavior. However, the lack of…

Date: 2026-09-17

Immune-related adverse events and clinical outcomes in advanced non-small cell lung cancer: does more toxicity predict better outcomes?

Abstract: Immune checkpoint inhibitors (ICIs) are a cornerstone of therapy for advanced non–small cell lung cancer (NSCLC). Elderly patients remain underrepresented in clinical…

Date: 2026-09-17

Neurological and hematological safety profiles of GSK-3? inhibitors: insights from multi-database pharmacovigilance and experimental validation

Abstract: Glycogen synthase kinase 3 beta (GSK-3?) inhibitors have received substantial attention for their therapeutic potential; however, their systemic safety profile remains…

Date: 2026-09-17

Clinical characteristics, management, and outcomes of lacrimal gland adenoid cystic carcinoma: a single-center series with contextual comparison to SEER data

Abstract: Lacrimal gland adenoid cystic carcinoma (LGACC) is a rare, aggressive malignancy with limited epidemiological data, particularly from East Asian populations. This…

Date: 2026-09-17