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Development and validation of a machine learning model based on multi-source clinical data for predicting the risk of early neurological deterioration in patients with ischemic stroke

Abstract: Early neurological deterioration (END) is a critical clinical event associated with poor patient outcomes after acute ischemic stroke. Early identification of high-risk…

Date: 2026-09-15

Modulation of cell migration and invasion of thyroid cancer cells using miRNA-enriched extracellular vesicles

Abstract: Extracellular vesicles (EVs) have been investigated as promising vehicles for delivering drugs and microRNAs (miRNAs) in distinct types of cancer. However, their use as…

Date: 2026-09-15

Development of a multidimensional disease burden assessment system for childhood neuroblastoma based on the social determinants of health theory

Abstract: To construct a multidimensional disease burden assessment system for children with neuroblastoma based on the Social Determinants of Health (SDH) theory, and to provide…

Date: 2026-09-15

Latent profile analysis and influencing factors of health literacy among family caregivers of cancer patients

Abstract: To understand the current status, categorical characteristics, and influencing factors of health literacy among family caregivers of cancer patients, providing evidence…

Date: 2026-09-15

A qualitative thematic comparative analysis of independent and AI-supported clinical reflections among medical interns

Abstract: Reflection is fundamental to medical education, supporting clinical reasoning, professional identity formation, and lifelong learning. Although generative artificial…

Date: 2026-09-15

Synergistic antitumor effect of HMGB2 targeting combined with MDM2 inhibitor in diffuse intrinsic pontine glioma therapy

Abstract: Diffuse intrinsic pontine glioma (DIPG) is a brain malignancy in children with a dismal prognosis. The high mobility group box 2 (HMGB2) is a member of the HMGB family…

Date: 2026-09-15

An upstream approach to veterinary workforce wellbeing: an evaluative review of an embedded wellbeing curriculum in veterinary education

Abstract: Veterinary professionals work in demanding environments shaped by individual, relational, organizational, and systemic pressures. Veterinary education can therefore…

Date: 2026-09-15

Prevalence and factors associated with self-reported sexually transmitted infections in Myanmar: analysis of national survey data

Abstract: Sexually transmitted infections (STIs) continue to pose a significant public health issue worldwide, especially in low- and middle-income countries (LMICs). However,…

Date: 2026-09-15

GATA2-driven ZNF486-JAM2 activation collaboratively counteracts epithelial-mesenchymal transition and in vitro invasion in endometrial cancer

Abstract: To investigate the role and molecular mechanism of the GATA2/ZNF486/JAM2 transcriptional regulatory axis in the invasion and migration of Uterine Corpus Endometrial…

Date: 2026-09-15

Association between perioperative optic nerve sheath diameter and postoperative delirium after Bentall surgery: a prospective observational study

Abstract: Optic nerve sheath diameter (ONSD) is an indirect, technique-dependent marker of intracranial pressure; its association with delirium after Bentall surgery remains…

Date: 2026-09-15