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Integrative single-cell and bulk transcriptomics uncovers a lipid metabolism-related lncRNA signature alongside the ELFN1-AS1/LYPLA1 axis driving osteosarcoma progression

Abstract: Osteosarcoma is the most prevalent primary malignant bone tumor in adolescents, featuring prominent intratumoral heterogeneity, early pulmonary metastasis and stagnant…

Date: 2026-09-11

Risk factors for post-traumatic lymphedema after open fractures of the lower leg: a retrospective cohort study

Abstract: Post-traumatic lymphedema (PTL) is an underrecognized complication of severe limb trauma and is characterized by persistent limb swelling. Patients with open fractures…

Date: 2026-09-11

Association of inflammatory markers with functional outcome after endovascular thrombectomy in anterior circulation stroke: a retrospective study

Abstract: Endovascular thrombectomy (EVT) is an effective treatment for acute ischemic stroke (AIS) caused by large vessel occlusion in the anterior circulation. However,…

Date: 2026-09-11

Posterior reversible encephalopathy syndrome (PRES) in children – a summary of 20 years of tertiary neurology centre experience

Abstract: Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological syndrome characterised by seizures, hypertension, visual disturbances alongside classical…

Date: 2026-09-11

Supporting frontline staff in frontotemporal degeneration research

Abstract: Clinical Research Coordinators (CRCs) serve as the frontline staff for research participants in studies on frontotemporal degeneration (FTD), directly influencing…

Date: 2026-09-11

Gut dysbiosis induced by sunflower oil-based sucrose-free high-fat diet leads to steatohepatitis

Abstract: High-fat diets (HFDs) are known to disrupt gut microbiota, contributing to obesity, inflammation, and metabolic disorders. Although sucrose is a known driver of gut…

Date: 2026-09-11

Mutant HVEM in lymphoma disrupts BTLA and CD160 regulation of anti-tumor signaling

Abstract: Somatic mutations can rewire tumor–immune interactions to favor cancer progression. Here, we define the functional impact of missense mutations in Herpesvirus entry…

Date: 2026-09-11

Metaplastic breast cancer: a clinicopathological analysis of nine cases highlighting diagnostic challenges and aggressive behavior

Abstract: Metaplastic breast cancer (MBC) is a rare and highly heterogeneous subtype of breast cancer associated with limited treatment options and a poor prognosis. We aimed to…

Date: 2026-09-11

Anlotinib plus PD-1 inhibitor in advanced soft tissue sarcoma: a real-world study on treatment patterns and treatment-emergent hypothyroidism

Abstract: Anlotinib was approved for advanced soft tissue sarcoma (STS) but validated biomarkers and optimal treatment patterns remain unclear. This study evaluated the efficacy,…

Date: 2026-09-11

Development of the perceived AI–physician consistency and trust scale for cardiology: a Delphi-based study

Abstract: Large language models (LLMs) have demonstrated considerable potential in cardiovascular diagnostic assistance and clinical decision support. A critical safety-related…

Date: 2026-09-11