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Serum 11-ketotestosterone is associated with overall disease-control status but adds limited information beyond androstenedione in children with 21-hydroxylase deficiency

Abstract: Monitoring children with 21-hydroxylase deficiency (21-OHD) requires suppression of adrenal androgen excess while avoiding glucocorticoid overtreatment. However, the…

Date: 2026-09-08

Evaluation of dermatological asymmetry measure of shape by histogram energy measure

Abstract: This study addresses automatic detection of skin changes especially asymmetry and symmetry of the lesions and their crucial role in the definition of dermatological…

Date: 2026-09-08

Association between severity of different body regions and inadequate control of atopic dermatitis: results from a cross-sectional and longitudinal study

Abstract: The Atopic Dermatitis Control Tool (ADCT) serves as a key metric for assessing atopic dermatitis (AD) management. However, the relationship between eczema severity in…

Date: 2026-09-08

PLAU promotes fibroblast activation and keloid fibrogenesis through PLAUR–Dependent TGF–?/Smad signaling

Abstract: Keloids are fibroproliferative disorders conditions of the dermis with dysregulated immune responses contributing to disease progression. However, the causal…

Date: 2026-09-08

Clinical spectrum of pediatric histoplasmosis in Mexico: description of seven cases and literature review

Abstract: Histoplasmosis is a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum (H.capsulatum) . It represents a diagnostic challenge in the pediatric…

Date: 2026-09-08

LLM and CQL computable phenotypes for myocarditis adverse event feature and outcome determinations using patient FHIR data: a feasibility study

Abstract: Post-market surveillance for adverse events of special interest is often constrained by key diagnostic elements being captured primarily in unstructured clinical notes…

Date: 2026-09-08

Reduced NLRP3, AIM2 and NLRC4 inflammasome activity in cord blood of extremely preterm infants

Abstract: Pro-in?ammatory caspase-1 is a key player in innate immunity. Physiological activation of the inflammasome/caspase-1 pathway supports host defense against pathogens,…

Date: 2026-09-08

Hydrocephalus management pathways in pediatric medulloblastoma: a retrospective cohort study

Abstract: To compare recorded postoperative intracranial infection and recurrent hydrocephalus across three hydrocephalus management pathways in children with medulloblastoma and…

Date: 2026-09-08

Right-to-left shunt is associated with reduced cerebral vascular reactivity in migraine patients with aura

Abstract: To investigate whether right-to-left shunt (RLS) associated with patent foramen ovale (PFO) is associated with altered cerebrovascular reactivity (CVR) in migraine…

Date: 2026-09-08

Long-term metabolic risks after thyroidectomy and thyroid hormone therapy in thyroid cancer survivors: a nationwide cohort study

Abstract: As long-term survival rates improve among thyroid cancer patients, the metabolic consequences of thyroidectomy and thyroid hormone therapy have gained increasing…

Date: 2026-09-08