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Spatial analysis of placentae during congenital cytomegalovirus infection suggests distinct cellular profiles in immune and trophoblast cells: an exploratory study

Abstract: Human cytomegalovirus (CMV) is the leading infectious cause of congenital birth defects worldwide. The placenta is a major route of vertical transmission, and both…

Date: 2026-10-12

Development and internal validation of a clinical prediction model for postoperative venous thromboembolism after neurosurgical intervention in patients with traumatic brain injury

Abstract: Venous thromboembolism (VTE) is a critical complication after traumatic brain injury (TBI) surgery. Conventional risk assessment tools were not developed for…

Date: 2026-10-12

High performance white blood cell classification using ensemble CNNs with Monte Carlo dropout and conformal prediction for clinical uncertainty quantification

Abstract: Automated classification of white blood cell (WBC) images may support cell-morphology workflows, but high accuracy alone does not establish clinical readiness. We…

Date: 2026-10-12

Incremental prognostic value of the T-helper 1/T-helper 2 immune phenotype and 72-h change in sequential organ failure assessment for in-hospital mortality in sepsis with and without type 2 diabetes: a retrospective two-cohort study

Abstract: Type 2 diabetes mellitus (T2DM) is accompanied by chronic immunometabolic dysregulation and may alter the host response to sepsis. We compared immunometabolic profiles…

Date: 2026-10-12

Development and validation of predictive models for the hemodialysis adequacy index (Kt/V) using multiple linear regression and machine learning algorithms

Abstract: Kt/V is a widely used indicator for assessing hemodialysis (HD) adequacy, but conventional measurement methods require blood sampling and are impractical for large-scale…

Date: 2026-10-12

A 2-year prognostic assessment of patients with coronary borderline lesions based on three-vessel quantitative flow ratio and the development and internal validation of a risk prediction nomogram

Abstract: To investigate the prognostic value of three-vessel quantitative flow ratio (3V-QFR) in patients with borderline coronary lesions (QFR 0.75–0.80) over a 2-year period;…

Date: 2026-10-12

Associations of cardiac autonomic modulation and urinary adrenal hormones with marathon finishing time in middle-aged male athletes

Abstract: The autonomic nervous and endocrine systems are involved in the physiological adaptation to exercise, and in experimental settings both the sympathovagal balance and the…

Date: 2026-10-12

A clinical-deep learning model for prolonged length of stay following endovascular aortic repair

Abstract: Prolonged length of stay (PLOS) after endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) is associated with increased complications, resource burden,…

Date: 2026-10-12

An update on freshwater gastropods serving as intermediate hosts of amphistomes infecting livestock in South Africa

Abstract: Improved surveillance of amphistome parasites and their intermediate hosts is crucial for comprehending their epidemiology and developing effective prevention and…

Date: 2026-10-12

Timing luteal urinary pregnanediol glucuronide assessment using urinary luteinizing hormone: agreement with ultrasound-determined ovulation

Abstract: Urinary pregnanediol glucuronide (PdG) is a non-invasive marker of luteal progesterone exposure, but its interpretation depends on timing relative to ovulation. We…

Date: 2026-10-12