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Early dynamics of eosinophils and the neutrophil-to-lymphocyte ratio are associated with severe immune-related adverse events during nivolumab therapy for metastatic renal cell carcinoma

Abstract: Reliable biomarkers for characterization of the risk of severe immune-related adverse events (irAEs) during immune checkpoint inhibition remain lacking. We hypothesized…

Date: 2026-10-12

Beyond binary: a novel anatomical-geographical-biological framework for perineural invasion risk stratification in oral squamous cell carcinoma – a proof-of-concept study

Abstract: Perineural invasion (PNI) is an adverse pathological feature in oral squamous cell carcinoma (OSCC) and an indication for adjuvant radiotherapy but is conventionally…

Date: 2026-10-12

Definitive radiotherapy versus surgery after neoadjuvant immunochemotherapy for locally advanced esophageal squamous cell carcinoma: a propensity score-matched study of efficacy and safety

Abstract: The optimal local treatment strategy for locally advanced esophageal squamous cell carcinoma (LA-ESCC) following neoadjuvant immunochemotherapy (NICT) remains…

Date: 2026-10-12

Integrative single-cell and bulk transcriptomic analysis identifies monocyte/macrophage senescence-associated candidate genes in pulmonary arterial hypertension

Abstract: Pulmonary arterial hypertension (PAH) is a progressive vascular disorder characterized by immune dysregulation and vascular remodeling. Cellular senescence modulates…

Date: 2026-10-12

Association of the lactate dehydrogenase-to-albumin ratio with all-cause and non-relapse mortality in patients with aGVHD after allogeneic HSCT: a single-center retrospective cohort study

Abstract: Acute graft-versus-host disease (aGVHD) remains a leading cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The…

Date: 2026-10-09

Cytarabine-based mobilisation yields higher CD34+ cell counts than cyclophosphamide regardless of prior daratumumab exposure in multiple myeloma

Abstract: Anti-CD38-based quadruplets such as daratumumab-bortezomib-lenalidomide-dexamethasone (D-VRd) or daratumumab-bortezomib-thalidomide-dexamethasone (D-VTd), where…

Date: 2026-10-09

Uric acid-to-high-density lipoprotein cholesterol ratio and incident vascular calcification in patients with type 2 diabetes mellitus: a retrospective cohort study

Abstract: The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) is a composite marker that has been associated with all-cause and cardiovascular mortality in…

Date: 2026-10-09

Th17/Treg imbalance and clinical characteristics in psoriasis patients with metabolic dysfunction-associated steatotic liver disease: a cross-sectional analysis

Abstract: Psoriasis is a chronic systemic inflammatory disease that imposes a considerable burden of metabolic comorbidities. Metabolic dysfunction-associated steatotic liver…

Date: 2026-10-09

Relative timelines for transition from a hospital ventilator to invasive home respiratory support after tracheostomy in infants with chronic respiratory failure

Abstract: Infants undergoing tracheostomy placement who require long-term mechanical ventilation are a growing population, and few studies have investigated the methods by which…

Date: 2026-10-09

From armed-conflict to care: clinical outcomes, diagnostic challenges, and psychosocial burden in children evaluated for suspected cancer displaced from Gaza and treated at a regional center of excellence

Abstract: Conflict-related displacement profoundly disrupts pediatric cancer care, yet clinical outcomes data for evacuated children treated at regional oncology centers remain…

Date: 2026-10-09