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Restlessness in cluster headache: unveiling the role of its key associations and clinical implications from a cohort study

Abstract: ICHD-3 recognizes restlessness/agitation as an accompanying feature of cluster headache (CH). However, its phenotypic significance within CH remains uncertain. We…

Date: 2026-10-05

Simple renal cysts are associated with ischemic stroke in young adults: a case–control study

Abstract: The incidence of ischemic stroke among young patients is increasing, and ischemic stroke has become a major cause of death and disability in young adults. The key to…

Date: 2026-10-05

Soluble TIM-3 and galectin-9 in cerebrospinal fluid are associated with disability at 6 months in aquaporin-4 IgG-positive neuromyelitis optica spectrum disorder

Abstract: Neuromyelitis optica spectrum disorders (NMOSD) are severe autoimmune diseases of the central nervous system characterized by autoantibodies against aquaporin 4…

Date: 2026-10-05

Longitudinal dynamics of serum neurofilament light chain and prognostic value for functional outcome after acute stroke: a prospective cohort study

Abstract: Serum neurofilament light chain (sNfL) is a blood biomarker of neuroaxonal injury, but its early longitudinal dynamics and prognostic value in clinically heterogeneous…

Date: 2026-10-05

Identification of psoriasis-associated hub genes by integrated transcriptomics and machine learning

Abstract: This study aims to systematically identify key hub genes in psoriasis pathogenesis through the integration of bioinformatics, machine learning and experimental…

Date: 2026-10-05

High EBV-reactive IgG levels in serum are linked to typical inflammatory cerebrospinal fluid features in multiple sclerosis

Abstract: Epstein-Barr virus (EBV) infection is strongly associated with multiple sclerosis (MS). However, it is ill-defined which of the MS-typical inflammatory alterations of…

Date: 2026-10-05

Vulnerability index impacts distribution of prostate cancer clinical trials in the United States

Abstract: Availability of clinical trials for prostate cancer in the US varies greatly by region. County-level analyses are vital to characterize healthcare access, disease…

Date: 2026-10-05

Multimodality salvage treatment incorporating ivonescimab plus chemotherapy for EGFR-mutated NSCLC with leptomeningeal metastases after dose-escalated third-generation EGFR-TKI failure: a retrospective study

Abstract: Leptomeningeal metastasis (LM) is among the most devastating modes of progression in EGFR-mutated non-small cell lung cancer (NSCLC). Although dose escalation of…

Date: 2026-10-05

Clinical characteristics and in-hospital prognostic factors in young patients with myocardial infarction

Abstract: This study aims to analyze the clinical characteristics and short-term prognostic factors of young patients with acute myocardial infarction. This retrospective…

Date: 2026-10-05

Remnant cholesterol, C-reactive protein, cholesterol-lowering medication, and cardiovascular outcome: novel findings from UK Biobank

Abstract: Despite substantial reductions in cardiovascular events with intensive LDL-C lowering, significant residual risk persists. Remnant cholesterol (RC) and C-reactive…

Date: 2026-10-05