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Association of clonal hematopoiesis of indeterminate potential with cardiovascular mortality in cardiovascular-kidney-metabolic syndrome: a large prospective cohort study

Abstract: Cardiovascular-kidney-metabolic (CKM) syndrome represents a progressive pathophysiological continuum. While clonal hematopoiesis of indeterminate potential (CHIP) is…

Date: 2026-10-07

Gastric involvement in multiple myeloma-associated AL amyloidosis: a case with serial endoscopy and a pooled analysis of 30 published cases

Abstract: To describe serial endoscopic findings in a patient with relapsed/refractory multiple myeloma (MM) and gastric amyloidosis and to summarize 30 published cases, with…

Date: 2026-10-06

Sex, BMI, skeletal maturation, and height among children and adolescents in high-altitude Xizang: a cross-sectional study

Abstract: Skeletal maturation influences the interpretation of childhood height, but its relationship with sex, body mass index (BMI), and attained height in children living at…

Date: 2026-10-06

High genetic predisposition and vertebral fracture burden in pregnancy and lactation-associated osteoporosis: clinical insights from a Taiwanese cohort

Abstract: Pregnancy and lactation-associated osteoporosis (PLO) is a rare disorder causing rapid bone loss and severe fragility fractures. While familial clusterings suggest…

Date: 2026-10-06

Diagnostic value of saline infusion test–derived biochemical parameters for primary aldosteronism subtyping

Abstract: Current clinical practice guidelines recommend adrenal venous sampling (AVS) for subtype classification in patients with primary aldosteronism (PA) who are candidates…

Date: 2026-10-06

Diabetes duration modifies the association between AIP and MAFLD in type 2 diabetes

Abstract: Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Although several insulin resistance…

Date: 2026-10-06

LncRNA ZFPM2 silencing alleviates lung epithelial injury by inducing M2 macrophage polarization: possible implication in bronchopulmonary dysplasia

Abstract: To screen the key long-chain non-coding RNA (LncRNA) closely related to the occurrence and development of Bronchopulmonary dysplasia (BPD), and explore its mechanism of…

Date: 2026-10-06

TREM2 + macrophages mediate anticancer therapy-induced immune evasion in lung adenocarcinoma via the CCL5/CCL22-Treg axis

Abstract: Osimertinib and cisplatin are widely used as standard treatments for non-small cell lung cancer (NSCLC); however, their effects on tumor microenvironment remodeling…

Date: 2026-10-06

Machine learning and nomogram for predicting severity of acute cholangitis: development and internal validation of a dual-framework model in a retrospective cohort study

Abstract: Accurate severity grading of acute cholangitis (AC) according to the Tokyo Guidelines 2018 (TG18) is essential for guiding biliary drainage decisions and intensive care…

Date: 2026-10-06

Integrated multi-omics and machine learning identify core mechanobiology-associated immune genes in pulmonary arterial hypertension

Abstract: Pulmonary arterial hypertension (PAH) involves vascular remodeling and altered mechanical signaling. The immune-associated transcriptomic changes accompanying this…

Date: 2026-10-06