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Soluble TIM-3 and galectin-9 in cerebrospinal fluid are associated with disability at 6 months in aquaporin-4 IgG-positive neuromyelitis optica spectrum disorder

Abstract: Neuromyelitis optica spectrum disorders (NMOSD) are severe autoimmune diseases of the central nervous system characterized by autoantibodies against aquaporin 4…

Date: 2026-10-05

Longitudinal dynamics of serum neurofilament light chain and prognostic value for functional outcome after acute stroke: a prospective cohort study

Abstract: Serum neurofilament light chain (sNfL) is a blood biomarker of neuroaxonal injury, but its early longitudinal dynamics and prognostic value in clinically heterogeneous…

Date: 2026-10-05

Identification of psoriasis-associated hub genes by integrated transcriptomics and machine learning

Abstract: This study aims to systematically identify key hub genes in psoriasis pathogenesis through the integration of bioinformatics, machine learning and experimental…

Date: 2026-10-05

High EBV-reactive IgG levels in serum are linked to typical inflammatory cerebrospinal fluid features in multiple sclerosis

Abstract: Epstein-Barr virus (EBV) infection is strongly associated with multiple sclerosis (MS). However, it is ill-defined which of the MS-typical inflammatory alterations of…

Date: 2026-10-05

Vulnerability index impacts distribution of prostate cancer clinical trials in the United States

Abstract: Availability of clinical trials for prostate cancer in the US varies greatly by region. County-level analyses are vital to characterize healthcare access, disease…

Date: 2026-10-05

Multimodality salvage treatment incorporating ivonescimab plus chemotherapy for EGFR-mutated NSCLC with leptomeningeal metastases after dose-escalated third-generation EGFR-TKI failure: a retrospective study

Abstract: Leptomeningeal metastasis (LM) is among the most devastating modes of progression in EGFR-mutated non-small cell lung cancer (NSCLC). Although dose escalation of…

Date: 2026-10-05

Clinical characteristics and in-hospital prognostic factors in young patients with myocardial infarction

Abstract: This study aims to analyze the clinical characteristics and short-term prognostic factors of young patients with acute myocardial infarction. This retrospective…

Date: 2026-10-05

Remnant cholesterol, C-reactive protein, cholesterol-lowering medication, and cardiovascular outcome: novel findings from UK Biobank

Abstract: Despite substantial reductions in cardiovascular events with intensive LDL-C lowering, significant residual risk persists. Remnant cholesterol (RC) and C-reactive…

Date: 2026-10-05

Chronic XBP1s-mediated activation of the unfolded protein response impairs CD8 + T cell anti-tumor immunity

Abstract: CD8 + T cells play a crucial role in anti-tumor immunity; however, their functionality is compromised by exhaustion driven by chronic antigen exposure, poor tumor…

Date: 2026-10-02

Heterogeneous profiles of eHealth literacy in older adults with type 2 diabetes: a latent profile analysis and associated factors

Abstract: Digital diabetes services are expanding rapidly in China, and older patients’ uptake of them depends on their eHealth literacy. This construct is usually reported as a…

Date: 2026-10-02