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Histone-related gene WDR77 promotes tumor progression through cell cycle regulation in skin cutaneous melanoma

Abstract: Skin cutaneous melanoma (SKCM) is extremely malignant, leading to poor prognosis. Epigenetic dysregulation, particularly histone modifications, contributes to disease…

Date: 2025-12-04

Male external genital skin disorders: a retrospective analysis from a tertiary hospital in China

Abstract: Male genital dermatoses encompass a diverse range of infectious, inflammatory, and neoplastic conditions with overlapping clinical presentations, often leading to…

Date: 2025-12-03

Impact of the COVID-19 pandemic waves on adults with moderate-to-severe atopic dermatitis in the Dutch general population: a population-based longitudinal cohort study

Abstract: This study aimed to investigate the impact of COVID-19 waves on mental health, pandemic-related wellbeing, and social functioning in adults with moderate-to-severe…

Date: 2025-12-02

Association between intraoperative dexmedetomidine and survival outcomes after colorectal cancer surgery: a retrospective cohort study

Abstract: The impact of dexmedetomidine (DEX) on postoperative survival outcomes in cancer remains controversial. Our study aimed to investigate the influence of intraoperative…

Date: 2025-12-02

Serum periostin as a novel biomarker and therapeutic target in coronary heart disease

Abstract: Coronary artery disease (CAD) remains a significant global contributor to morbidity and mortality, necessitating a deeper understanding of its molecular mechanisms. This…

Date: 2025-12-02

Commensal Staphylococci attenuate Staphylococcus aureus skin colonization and inflammation via AHR-dependent signaling

Abstract: Staphylococcus aureus is the leading cause of bacterial skin infections in several inflammatory skin diseases, however, is rarely detected on healthy skin. Skin barrier…

Date: 2025-12-01

IL-9 and IL-24 biomarkers in the transcriptional signature of contact dermatitis to methylisothiazolinone

Abstract: Allergic contact dermatitis (ACD) is a cutaneous inflammatory disorder mediated by allergen-specific memory T cells. Methylisothiazolinone (MI), a preservative widely…

Date: 2025-11-28

Iron deficiency anemia and the risk of new-onset tinnitus in female patients: a cohort study

Abstract: Iron deficiency anemia (IDA) may compromise auditory function through cochlear hypoxia and altered hemodynamics; however, longitudinal evidence linking IDA to tinnitus…

Date: 2025-11-28

Associations between COVID-19 impact and subsequent substance use in adolescents with chronic pain

Abstract: The current cross-sectional study retrospectively investigated associations between COVID-19-related factors and subsequent substance use in adolescents with chronic…

Date: 2025-11-28

Real-world efficacy and safety of dupilumab in the treatment of head and neck atopic dermatitis: a retrospective cohort study

Abstract: Head and neck atopic dermatitis (HNAD) is a clinically common subtype of AD. While dupilumab is widely used in AD treatment, its efficacy in HNAD is debatable. This…

Date: 2025-11-27