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A composite score of serum cytokines enables early identification of patients at high risk for irAEs under immune checkpoint inhibition

Abstract: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of advanced skin cancers. However, potentially severe and irreversible immune-related adverse events…

Date: 2025-11-27

The influencing factors of postoperative sleep disorders in elderly patients undergoing hip replacement surgery under general anesthesia and the construction and validation of a nomogram prediction model

Abstract: To explore the influencing factors of postoperative sleep disorders in elderly patients undergoing hip replacement (HR) under general anesthesia, and to construct and…

Date: 2025-11-27

Gallic acid alleviates visceral hyperalgesia following maternal separation in mice by inhibiting EphrinB2/EphB2 signaling mediated activation of neurons and glial cells

Abstract: Early life stress (ELS) causes functional gastrointestinal issues linked to visceral hyperalgesia. Activation of spinal neurons and glial cells is key to the development…

Date: 2025-11-27

S-1 maintenance chemotherapy following definitive chemoradiotherapy in high-risk locally advanced nasopharyngeal carcinoma: a propensity score-matched analysis

Abstract: To evaluate the efficacy and safety of S-1 maintenance chemotherapy after definitive chemoradiotherapy in patients with high-risk, locally advanced nasopharyngeal…

Date: 2025-11-26

Serum creatinine-to-cystatin C ratio and 1-year mortality risk in advanced breast cancer patients: a multicenter retrospective cohort study

Abstract: Muscle wasting and sarcopenia in advanced breast cancer correlates with poor outcomes. The serum creatinine-to-cystatin C ratio (CCR) is a potential muscle mass…

Date: 2025-11-26

Single center experience of the impact of artificial intelligence image analysis software on short-term prognosis of non-small cell lung cancer

Abstract: To explore the single center experience of the value of artificial intelligence image analysis software in short-term prognostic assessment of non-small cell lung…

Date: 2025-11-26

Compare the prognosis of pancreatic cancer patients with different treatment modalities and use machine learning methods to build predictive models

Abstract: Pancreatic cancer (PC) is highly refractory to most treatments. Multimodal treatment, combining several types of therapies, is likely to benefit PC patients. However, it…

Date: 2025-11-26

Optimized BERT-based NLP outperforms zero-shot methods for automated symptom detection in clinical practice

Abstract: Large Language Models (LLMs) have raised broad expectations for clinical use, particularly in the processing of complex medical narratives. However, in practice, more…

Date: 2025-11-26

The genetic landscape of congenital neutropenia in Poland: summary of the nationwide screening campaign

Abstract: This work summarizes 15 years of genetic research on neutropenia in the Polish pediatric cohort, explores the distribution and spectrum of disease-causing genetic…

Date: 2025-11-26

Effect, safety, timing and dose of thoracic radiotherapy plus third-generation EGFR-TKIs as first-line treatment in patients with EGFR-mutated oligo-organ metastatic NSCLC

Abstract: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-based combination therapy modalities for patients with EGFR-mutated stage IV non-small cell lung…

Date: 2025-11-26