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Association study between intestinal microbiota dysbiosis in inflammatory bowel disease and the global disease burden growth trend

Abstract: Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a group of chronic intestinal inflammatory diseases. Its incidence and prevalence…

Date: 2025-11-26

Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis

Abstract: Evidence suggested that capsaicin may protect against steatotic liver disease (SLD), but these findings lack validation in population-based studies. This research aimed…

Date: 2025-11-26

Epilepsy-associated CHD2 missense variants and optimization strategies for genetic diagnosis: a comparative analysis of algorithms

Abstract: The CHD2 gene is one of the most common causative genes of developmental and epileptic encephalopathy (DEE). With the advent of high-throughput sequencing, identifying…

Date: 2025-11-26

Videonystagmography features and clinical symptoms correlate with Parkinson's clinical subtypes

Abstract: Analyzing the differences in video-nystagmography (VNG) parameters among Parkinson's disease (PD) patients with distinct motor subtypes and evaluate the correlation…

Date: 2025-11-26

Administration of eptifibatide as rescue therapy during mechanical thrombectomy in acute ischemic stroke

Abstract: The success of the technical implementation of mechanical thrombectomy (MT) depends on many factors. Considering the experience of the interventional radiologist and the…

Date: 2025-11-26

SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway–targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trials

Abstract: Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) have shown efficacy in the treatment of migraine. However, certain comorbidities have been…

Date: 2025-11-26

Single-cell transcriptomics identifies FOSL1-regulated IGFBP3+ melanoma subtype as a neuro-immunoregulatory signaling hub facilitating tumor progression

Abstract: The most aggressive type of skin cancer, melanoma, has a high prevalence of metastases and a poor prognosis. Despite advancements in treatment, drug resistance and tumor…

Date: 2025-11-26

Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection

Abstract: The analysis of tumor-infiltrating lymphocytes often requires techniques that expand their numbers, potentially introducing bias. To address this, we performed a…

Date: 2025-11-26

Long-term outcomes and patterns of failure after empiric SBRT for presumed early-stage lung tumors

Abstract: Stereotactic body radiation therapy (SBRT) is the established standard of care for medically inoperable early-stage non-small cell lung cancer (ES-NSCLC). When a biopsy…

Date: 2025-11-25

Comparative efficacy of r-hFSH Alfa + r-LH versus r-hFSH delta + hMG in poor ovarian responders

Abstract: Poor ovarian response (POR) remains a major limitation in assisted reproductive medicine. Direct comparisons between r-hFSH alfa + r-LH and r-hFSH delta + hMG in this…

Date: 2025-11-25