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Maternal obesity in low-resource settings: a multicenter cohort study of labor and neonatal outcomes in Guinea

Abstract: This study aimed to evaluate the impact of maternal obesity on obstetrical outcomes, including labor and delivery parameters, as well as maternal and neonatal prognosis.…

Date: 2025-11-20

Global and regional burdens of opioid use disorder from 1990 to 2021, with future forecasts to 2050: a systematic analysis for the global burden of disease study 2021

Abstract: This study comprehensively investigated the magnitude and temporal trends of the global burden of opioid use disorder (OUD) from 1990 to 2021 and predicted the disease…

Date: 2025-11-20

Aqueous humor levels of syndecan-1 and syndecan-4 associated with OCTA metrics in diabetic retinopathy

Abstract: Attenuated endothelium glycocalyx had been shown to be related to vascular damage during diabetic retinopathy (DR). Syndecans were pivotal components of retinal…

Date: 2025-11-20

The necessity of ulnar osteotomy in children with missed Monteggia fractures

Abstract: The aims of this study were to review our cases of missed Monteggia fracture treated by open reduction of the radial head with or without ulnar osteotomy and to…

Date: 2025-11-20

Application of functional magnetic resonance imaging in identifying responsible brain regions associated with spinal diseases related pain

Abstract: Spinal diseases related pain represents a critical clinical issue that demands urgent resolution. Current treatment and assessment strategies predominantly focus on…

Date: 2025-11-20

Three-dimensional anatomical characterization of the sustentaculum tali in asymptomatic adults: a computed tomography-based morphometric analysis

Abstract: This study aimed to establish normative anatomical references for the sustentaculum tali and talar articular surface using three-dimensional CT imaging, and to develop…

Date: 2025-11-20

Application and evaluation of online-offline experiential teaching in obstetric training for “First 1000 Days of Life” child healthcare

Abstract: To evaluate the clinical effectiveness and mechanisms of an online-offline experiential teaching model in the “First 1000 Days of Life” child healthcare training for…

Date: 2025-11-20

Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients

Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immunotherapy because of its highly immunosuppressive tumor microenvironment. Aryl hydrocarbon…

Date: 2025-11-20

Delayed-onset parkinsonism is common after isolated striatal infarcts

Abstract: While case studies have suggested that only a minority of patients with putaminal lesions develop parkinsonism, existing data are limited by involvement of adjacent…

Date: 2025-11-20

Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosis

Abstract: Ionizing radiation causes immune dysfunction, increasing susceptibility to infection and mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) is released…

Date: 2025-11-20