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The mechanism regulating the cytotoxicity of ?? T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis

Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health threat. ?? T cells, critical innate immune responders, provide rapid anti-TB…

Date: 2026-01-28

Impact of prophylaxis, inhibitors, and genetics on joint outcomes according to the IPSG-MRI score in hemophilia A, B and vWD type 3

Abstract: Hemophilia A (HA) and hemophilia B (HB) are X-linked-bleeding disorders caused by deficiency of clotting factors VIII and IX, while von Willebrand disease (vWD) type 3…

Date: 2026-01-27

Assessing venous thromboembolism risk in lung cancer: a comprehensive evaluation of the khorana score, clinical characteristics, and incidence of thrombosis

Abstract: Venous thromboembolism (VTE) occurrence in patients with lung cancer is associated with significant morbidity and mortality. The Khorana Score (KRS) is a validated risk…

Date: 2026-01-27

The predictive value of interleukin-2 receptor and prognostic nutritional index in patients with diffuse large B-cell lymphoma

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma (NHL), accounting for 30–40% of NHL cases. It exhibits high heterogeneity in…

Date: 2026-01-27

Development and validation of a prediction model for urinary tract infection in older patients with type 2 diabetes mellitus

Abstract: To analyze the pathogen distribution of older type 2 diabetes mellitus (T2DM) patients with urinary tract infection (UTI) and to develop and validate the feasibility of…

Date: 2026-01-27

Association between triglyceride-glucose index and heart failure in patients with type 2 diabetes mellitus: a cross-sectional study

Abstract: This study aimed to investigate the association between the triglyceride-glucose (TyG) index and heart failure (HF) in patients with type 2 diabetes mellitus (T2DM).…

Date: 2026-01-27

A 76-week real-world multidimensional analysis of guselkumab in moderate to severe plaque psoriasis: a retrospective cohort study based on Chinese clinical practice standards

Abstract: Guselkumab, a monoclonal antibody targeting IL-23p19, has shown durable efficacy and safety in global phase III trials and real-world studies. However, in Chinese…

Date: 2026-01-27

Resting-state MEG of whole-brain functional network in cingulate gyrus epilepsy

Abstract: To investigate the connectivity and formation mechanism of the whole brain resting-state network in cingulate gyrus epilepsy and to identify biological markers and…

Date: 2026-01-27

Application and safety analysis of paravertebral block with dezocine and ropivacaine in video-assisted thoracoscopic surgery for lung cancer

Abstract: This study aimed to analyze the application and safety of different doses of dezocine combined with ropivacaine for thoracic paravertebral block (TPVB) in video-assisted…

Date: 2026-01-27

Psychiatric outcomes after primary and secondary earthquake exposure: effects of loss, media, and treatment

Abstract: Earthquakes can cause substantial psychiatric morbidity including Post-Traumatic Stress Disorder (PTSD). While direct exposure effects are well known less is understood…

Date: 2026-01-27