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Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection with Listeria monocytogenes and lymphocytic choriomeningitis virus

Abstract: Efficient phagocytosis of pathogens is a key effector function of the innate immune system. Impaired phagocytic activity can result in uncontrolled pathogen…

Date: 2026-01-27

Gemcitabine-docetaxel therapy in pediatric patients with relapsed or refractory sarcoma: a single-center experience

Abstract: The prognosis for pediatric patients with relapsed or refractory sarcoma remains poor, and standard salvage therapies are lacking. This study evaluated the efficacy and…

Date: 2026-01-26

Validation of blood-based indices associated with sarcopenia for the prediction of pneumonia and delirium in patients with acute withdrawal from excessive alcohol consumption

Abstract: This study aimed to explore the hematology-derived relationship between the blood-based indices associated with sarcopenia including the neutrophil-lymphocyte ratio…

Date: 2026-01-26

The impact of radioligand therapy on prognosis in patients with lung neuroendocrine tumors

Abstract: Evidence on the efficacy and safety of radioligand therapy (RLT) in lung neuroendocrine tumors (LNETs) remains scarce. The limited data available, derived mainly from…

Date: 2026-01-26

Shenqi compound enhances pancreatic ?-cell secretion by promoting the maturation and transport of insulin secretory vesicles through the NOD1/RIP2 signaling pathway

Abstract: Shenqi compound (SQC) is an effective prescription in Chinese medicine to enhance glucose homeostasis and protect pancreatic cells from high glucose-induced damage.…

Date: 2026-01-26

Humanized anti-CD33 CAR-T cells and antibody-drug conjugates for targeted therapy in acute myeloid leukemia

Abstract: Acute myeloid leukemia (AML) is a malignant disorder originating from myeloid hematopoietic stem and progenitor cells. Despite the availability of current treatment…

Date: 2026-01-26

Global trends and future projections of cervical cancer burden: an integrated analysis of GBD 2021, UN population and WHO HPV vaccination data

Abstract: Cervical cancer remains a leading cause of morbidity and mortality among women, disproportionately affecting low- and middle-income countries (LMICs). We sought to: (1)…

Date: 2026-01-26

The role of satisfaction with care among factors affecting health-related quality of life in people with cancer: a cross-sectional study

Abstract: Despite advances in therapies that have increased the duration of post-diagnosis survival, living with long-term adverse effects of cancer and its treatment is common.…

Date: 2026-01-26

Gender-specific motivation for training in sexual history

Abstract: Although sexual history taking is an essential component of a comprehensive medical history, it is often omitted in practice. To ensure competent assessment, this skill…

Date: 2026-01-26

Combining 3D printing technology with customized metal plates for the treatment of long segment femoral shaft comminuted fractures

Abstract: This study aims to evaluate the clinical value of combining 3D printing technology with customized metal plates in the treatment of long-segment femoral shaft comminuted…

Date: 2026-01-26