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The impact of frailty on cognitive outcomes in elderly patients with post-stroke subjective cognitive complaints

Abstract: Frailty delineates a state of poor health characterized by the accumulation of age-related health deficits, and was associated with cognitive decline in patients with…

Date: 2025-11-19

Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing off

Abstract: To compare the efficacy and safety of direct switch from levodopa/benserazide (LB) to levodopa/carbidopa/entacapone (LCE) versus LB plus pramipexole (PPX) in Chinese…

Date: 2025-11-19

Self-perceptions of aging and sarcopenia in older adults: the mediating role of IADL

Abstract: Sarcopenia, marked by declines in muscle mass and function, poses a major risk to healthy aging. Self-perceptions of aging (SPA) reflect individuals’ attitudes toward…

Date: 2025-11-19

Correlation study between serum uric acid level and cognitive impairment in middle-aged and elderly patients with hypertension: based on an explainable predictive model

Abstract: Patients with primary hypertension are always comorbid with hyperuricemia. Serum uric acid exhibits a dual role in cognitive function. Evidence regarding the…

Date: 2025-11-19

Cortical morphometric similarity patterns and molecular signatures across ischemic stroke recovery

Abstract: Ischemic stroke is associated with widespread and dynamic brain structural alterations, but the relationship between these changes and underlying molecular signatures…

Date: 2025-11-19

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

Abstract: Interleukin-35 (IL-35), consisting of two subunits - Ebi3 and p35, is a pleiotropic anti-inflammatory cytokine implicated in fetal tolerance and pregnancy maintenance.…

Date: 2025-11-19

CD20+ and CD204+ exhibit distinct prognostic associations in thymic epithelial tumors

Abstract: Thymic epithelial tumors (TETs), encompassing thymomas and thymic carcinomas, are rare malignancies originating from thymic epithelial cells. This study aimed to…

Date: 2025-11-18

First-line immune checkpoint inhibitors combined with chemotherapy in advanced large-cell neuroendocrine carcinoma of the lung: a real-world retrospective study

Abstract: Large-cell neuroendocrine carcinoma of the lung (LCNEC) shares clinicopathological features with both small cell lung cancer (SCLC) and non-small cell lung cancer…

Date: 2025-11-18

Prediction model and significance of myocardial injury induced by fluorouracil combined with platinum-based chemotherapy in advanced gastric cancer based on baseline data and inflammation-nutrition-atherosclerosis factors

Abstract: To develop and evaluate a predictive model for myocardial injury in patients with advanced gastric cancer treated with fluorouracil plus platinum-based chemotherapy,…

Date: 2025-11-18

How to predict progression-free survival in patients with grade 2 IDH-mutated diffuse gliomas after surgery: a long-term follow-up analysis

Abstract: Available prognostic scores for adult-type diffuse glioma with isocitrate dehydrogenase (IDH) mutant were validated before the evaluation of biomolecular features. The…

Date: 2025-11-18