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Beyond traditional—the sick cirrhosis patient scores integrating cytokine and immune profiling for precision prognosis in hospitalized cirrhosis patients may help predict infection, ICU admission and long-term death post hospitalization

Abstract: Inflammatory biomarkers and immune cell function may provide prognostic value beyond traditional severity scores in hospitalized cirrhosis patients. We aimed to…

Date: 2026-01-21

MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary ?-tryptasemia

Abstract: Hereditary ?-tryptasemia (H?T), defined by increased TPSAB1 copy number and elevated basal serum tryptase, is associated with mast cell (MC)–mediated symptoms. However,…

Date: 2026-01-21

Pro-inflammatory dietary patterns and their association with cardiovascular disease and pancreatic cancer in a hospital population: a cross-sectional study

Abstract: To examine whether a concise, clinic-feasible Patient Inflammatory Diet Score (PIDS) relates to prevalent pancreatic cancer and cardiovascular disease (CVD) in a…

Date: 2026-01-21

Real-world use of efgartigimod in acetylcholine receptor antibody–positive generalized myasthenia gravis: experience from two centers in Greece and Cyprus

Abstract: Efgartigimod, an FcRn antagonist that reduces circulating immunoglobulin G (IgG), is approved for the treatment of acetylcholine receptor (AChR) antibody–positive…

Date: 2026-01-21

The impact of STING signaling on myeloid cells highlights macrophages as the major player in controlling Brucella abortus

Abstract: Brucellosis, caused by Brucella abortus ( Ba ), is one of the most common zoonoses worldwide. Some components of the bacteria can be recognized by the innate immune…

Date: 2026-01-21

Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine

Abstract: The development of an effective HIV-1 vaccine is of paramount importance to global health. Here, we compared the influence of two adjuvants, Escherichia coli…

Date: 2026-01-21

Dupilumab treatment is not associated with changes in lymphoma risk in atopic dermatitis and other type 2 inflammatory diseases: data from a large-scale retrospective cohort study

Abstract: The association between atopic dermatitis (AD) and lymphoma risk remains inconclusive. Dupilumab, approved for moderate-to-severe AD, has been linked to an increased…

Date: 2026-01-20

Post-licensure safety surveillance of 9-valent human papillomavirus vaccine using the vaccine adverse event reporting system, 2014–2024

Abstract: On December 10, 2014, the Food and Drug Administration (FDA) licensed the 9-valent human papillomavirus vaccine (9vHPV) for prevention of HPV-related cancers and genital…

Date: 2026-01-20

Association between iron deficiency anemia and the risk of new-onset tuberculosis infection: a matched cohort analysis

Abstract: Tuberculosis remains a major global health challenge, with emerging evidence suggesting that micronutrient deficiencies may contribute to susceptibility to infection…

Date: 2026-01-20

Associations of eosinophil-to-monocyte ratio and C-reactive protein-to-high-density lipoprotein cholesterol ratio with early neurological deterioration after thrombolysis in acute ischemic stroke

Abstract: Inflammation mechanisms play critical roles in acute ischemic stroke (AIS). However, the correlations of the eosinophil-to-monocyte ratio (EMR) and blood C-reactive…

Date: 2026-01-20