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Development and comparison of multivariate diagnostic models for rapidly progressive central precocious puberty in girls: the role of serum osteocalcin

Abstract: To develop a diagnostic prediction model for rapidly progressive central precocious puberty (RP-CPP) and evaluate the contribution of osteocalcin(OC) to the model. For a…

Date: 2026-01-19

Comparison of endovascular treatment outcomes in stroke patients with cardioembolic or intracranial atherosclerosis-predisposed large vessel occlusion

Abstract: The benefit of endovascular treatment (EVT) in patients with acute ischemic stroke due to large vessel occlusion is now well established. EVT is highly effective for…

Date: 2026-01-19

Admission NIHSS score and diabetes as independent predictors of in-hospital early neurological improvement following mechanical thrombectomy: a retrospective cohort study

Abstract: Accurate early prognostication in acute ischemic stroke (AIS) is essential for optimizing post-thrombectomy management strategies. However, the predictive utility of…

Date: 2026-01-19

Impact of treatment interruption on the efficacy and safety of vunakizumab in patients with moderate-to-severe plaque psoriasis: a post-hoc analysis of a phase 3 trial

Abstract: Vunakizumab, a novel IL-17A inhibitor, has demonstrated satisfactory efficacy and safety for the treatment of moderate-to-severe plaque psoriasis. This analysis aimed to…

Date: 2026-01-16

Sibling-controlled study of the impact of dietary therapy on the gut microbiota in children with phenylketonuria

Abstract: Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by a deficiency of phenylalanine hydroxylase activity. Due to intolerance to the dietary intake…

Date: 2026-01-16

Real-world effectiveness of SGLT2 inhibitors in patients with HF and ESKD: a multicenter cohort study

Abstract: Patients with heart failure (HF) and end-stage kidney disease (ESKD) face a high burden of mortality and hospitalization, yet effective therapeutic options remain…

Date: 2026-01-16

Effect of tidal volume on gastric insufflation during laparoscopic cholecystectomy: a strictly retrospective observational study

Abstract: Laparoscopic cholecystectomy (LC) is the gold-standard minimally invasive gallbladder removal procedure. Optimal ventilation during LC requires positive end-expiratory…

Date: 2026-01-16

Disruption of normal saline supply chain due to a disaster: an analysis of the impact of normal saline shortage on anesthesia practice in a large hospital system and models toward resiliency

Abstract: In the wake of the COVID-19 pandemic and upheaval in the global supply chain, the healthcare sector has grappled with acute shortages of essential resources. Such…

Date: 2026-01-16

Sedation level variability an indicator for mortality in mechanical ventilated critically ill patients: a propensity score-weighted cohort study

Abstract: To investigate the impact of low versus high sedation level variability (SLV), measured during the first 72-h intensive care unit (ICU) stay, on clinical outcomes in…

Date: 2026-01-16

Adverse event prediction in propofol-remimazolam tosilate anesthesia

Abstract: This study aimed to develop and validate a predictive model for anesthesia-related adverse events (ARAEs) in patients receiving propofol combined with remimazolam…

Date: 2026-01-15