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Factors influencing health behavior changes in people with early multiple sclerosis: process evaluation of the multicenter randomized controlled POWER@MS1 trial

Abstract: Health behavior changes, i.e., optimizations of physical activity, diet, sleep and stress management, are increasingly considered as modifiers of prognostic risk in…

Date: 2025-10-27

Elevated IL-6, IL-10, and IFN-? levels in fatal elephant endotheliotropic herpesvirus – hemorrhagic disease cases suggest an excessive proinflammatory cytokine response contributes to pathogenesis

Abstract: Hemorrhagic disease developed as a consequence of an EEHV infection (EEHV-HD) is the leading cause of death of young Asian elephants in Zoos worldwide and also affects…

Date: 2025-10-27

Engineered multifunctional transforming growth factor-? type II receptor ectodomain fusions for oncology applications

Abstract: The transforming growth factor-? (TGF-?) superfamily consists of a large number of evolutionarily conserved and structurally related polypeptide growth factors. TGF-?…

Date: 2025-10-27

Initial experience of spatially fractionated lattice radiation therapy for palliative treatment of pediatric bulky tumors

Abstract: Spatially fractionated radiation therapy (SFRT) has demonstrated high clinical response rates with minimal toxicity in adult patients with bulky tumors, including…

Date: 2025-10-27

An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

Abstract: The tumor microenvironment (TME) plays a crucial role in cancer progression, yet the interactions between tumor cells and stromal components, such as fibroblasts, remain…

Date: 2025-10-27

Preoperative absolute neutrophil count: a potential indicator for prognosis in carcinoembryonic antigen normal stage I non-small cell lung cancer

Abstract: Carcinoembryonic antigen (CEA) is still the most valuable tumor marker in the diagnosis and prognosis of non-small cell lung cancer (NSCLC) patients; however, its…

Date: 2025-10-27

Dose response test of patient-derived cancer organoids to irradiation

Abstract: Patient-derived cancer organoids emerged as an innovative model in basic and translational medicine research, as well as precision medicine. However, most radiation…

Date: 2025-10-27

Effects of menopausal hormone therapy on gut microbiota in postmenopausal women and the relationship with bone metabolism

Abstract: Menopausal Hormone Replacement Therapy (MHT) is widely used by peri- and post-menopausal women to alleviate menopause-related symptoms and preventing bone loss, but the…

Date: 2025-10-27

Analysis of risk factors and development of a prediction model for long-term prognosis in patients with ischemic heart failure after percutaneous coronary intervention

Abstract: This study aimed to investigate the factors influencing the long-term prognosis of patients with ischemic heart failure (IHF) after percutaneous coronary intervention…

Date: 2025-10-27

Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment

Abstract: As a major contributor to global death rates, coronary heart disease (CHD) remains critical. This investigation examines CD147's utility for assessing plaque…

Date: 2025-10-27